1346758-73-3

Upstream product

• 1346758-66-4 1,7,7-trimethylbicyclo[2.2.1]hepta-2,5-diene-2,5-diyl bis(trifluoromethanesulfonate) 
• 1765-93-1 4-fluoroboronic acid 
• 2758-63-6 (1S,4S)-1,7,7-trimethylbicyclo[2.2.1]heptane-2,5-dione 
• 10293-02-4 (1S,2R)-1-methyl-2-hydroxy-7,7-dimethyl-bicyclo[2.2.1]hept-5-one 
• 10293-01-3 5-oxobornyl acetate 

Relevant academic research and scientific papers

Methods for preparation of apremilast

The present invention discloses a method for preparation of Apremilast. β-phthalimino vinylsulfones are reacted through the asymmetric addition reaction to form an addition product, and the drug of Apremilast can be obtained from the addition product through simple reactions. The method is a process for synthesizing Apremilast in a more efficient way.

CHIRAL DIENE LIGANDS, A FABRICATION METHOD THEREOF AND APPLICATIONS THEREOF

The present invention proposes a chiral diene ligand, a fabrication method thereof and applications thereof. The chiral diene ligand is a bicyclo[2.2.1] diene ligand having structural specificity and high stability, which favors the bicyclo[2.2.1] diene l

Expanding the C1-symmetric bicyclo[2.2.1]heptadiene ligand family: Highly enantioselective synthesis of cyclic β-aryl-substituted carbonyl compounds

The efficient preparation of highly enantioenriched cyclic β-aryl-substituted carbonyl compounds has been achieved through the Rh I-catalyzed asymmetric 1,4-addition of an array of arylboronic acids to cyclic α,β-unsaturated carbonyl compounds. In the presence of 0.1 or 0.5 mol-% of the RhI/1g complex, the products of conjugate addition were isolated in 89 to 98%ee and in good to excellent yield.

Highly enantioselective rhodium-catalyzed asymmetric 1,4-addition reactions of arylboronic acids to acyclic α,β-unsaturated compounds: The formal synthesis of (-)-indatraline

It's do or diene: Stable chiral bicyclo[2.2.1]diene ligands were synthesized from (-)-5-oxobornyl acetate and utilized in the asymmetric 1,4-addition reaction of arylboronic acids with acyclic α,β- unsaturated compounds. Low catalytic loading of the compl