1346911-21-4

Basic information

• Product Name: C₂₅H₂₁Cl₂N₃O₃
• Synonyms: C₂₅H₂₁Cl₂N₃O₃
• CAS NO: 1346911-21-4
• Molecular Weight: 482.366
• Mol File: 1346911-21-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₂₅H₂₁Cl₂N₃O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₅H₂₁Cl₂N₃O₃(1346911-21-4)
• EPA Substance Registry System: C₂₅H₂₁Cl₂N₃O₃(1346911-21-4)

Safety Data

• Hazardous Substances Data: 1346911-21-4(Hazardous Substances Data)

Upstream product

• 2107-69-9 5,6-dimethoxy-1-indanone 
• 1260498-71-2 C₁₈H₁₅ClO₃ 
• 69194-89-4 p-chlorophenylsemicarbazide 

Relevant articles and documents

POMA analyses as new efficient bioinformatics' platform to predict and optimise bioactivity of synthesized 3a,4-dihydro-3H-indeno[1,2-c]pyrazole-2- carboxamide/carbothioamide analogues

A series of 43, 3a,4-dihydro-3H-indeno[1,2-c]pyrazole-2-carboxamide/ carbothioamide analogues (D01-D43) were analysed using Petra, Osiris, Molinspiration and ALOGPS (POMA) to identify pharmacophore, toxicity prediction, lipophilicity and bioactivity. All the compounds were evaluated for anti-HIV activity. 3-(4-Chlorophenyl)-N-(4-fluorophenyl)-6,7-dimethoxy-3a,4-dihydro-3H- indeno[1,2-c]pyrazole-2-carboxamide (D07) was found to be the most active with IC50 > 4.83 μM and CC50 4.83 μM. 3-(4-Fluorophenyl)-6,7-dimethoxy-3a,4-dihydro-3H-indeno[1,2-c] pyrazole-2-carbothioamide (D41) was found to be the most active compound against bacterial strains with MIC of 4 μg/ml, comparable to the standard drug ciprofloxacin while 3-(4-methoxyphenyl)-6,7-dimethoxy-3a,4-dihydro-3H-indeno[1, 2-c]pyrazole-2-carboxamide (D38) was found to be the most active compound against fungal strains with MIC 2-4 μg/ml, however less active than standard fluconazole. Toxicities prediction by Osiris were well supported and experimentally verified with exception of some compounds. In anticonvulsant screening, 3-(4-fluorophenyl)-N-(4-chlorophenyl)-6,7-dimethoxy-3a,4-dihydro-3H- indeno[1,2-c]pyrazole-2-carboxamide (D09) showed maximum activity showing 100% (4/4, 0.25-0.5 h) and 75% (3/4, 1.0 h) protection against minimal clonic seizure test without any toxicity.