1346933-33-2Relevant academic research and scientific papers
Facing the gem-dialkyl effect in enzyme inhibitor design: Preparation of homocycloleucine-based azadipeptide nitriles
Frizler, Maxim,Lohr, Friederike,Luelsdorff, Michael,Guetschow, Michael
, p. 11419 - 11423 (2011/11/29)
A tough nut to crack: In contrast to azadipeptide nitriles containing a P2 leucine residue, the synthesis of the corresponding homocycloleucine-based inhibitors was more difficult; possibly due to the gem-dialkyl effect. A synthetic route to the first hom
