1347008-89-2

Upstream product

• 5470-22-4 4-chloropicolinic acid 
• 19235-89-3 4-chloro-pyridine-2-carbonitrile 
• 56074-07-8 4-acetamido-3-chlorophenol 

Downstream Products

• 1347008-93-8 C₁₅H₁₀ClF₃N₄O 
• 1347008-64-3 1-(2-chloro-4-(2-(5-(trifluoromethyl)-1H-imidazol-2-yl)pyridin-4-yloxy)phenyl)-3-(4-fluoro-3-(trifluoromethyl)phenyl)urea 
• 1347008-66-5 1-(2-chloro-4-(2-(5-(trifluoromethyl)-1H-imidazol-2-yl)pyridin-4-yloxy)phenyl)-3-(2-chloro-5-(trifluoromethyl)phenyl)urea 
• 1347008-69-8 1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2-chloro-4-(2-(5-(trifluoromethyl)-1H-imidazol-2-yl)pyridin-4-yloxy)phenyl)urea 
• 1347008-73-4 1-(2-chloro-4-(2-(5-(trifluoromethyl)-1H-imidazol-2-yl)pyridin-4-yloxy)phenyl)-3-(4-methyl-3-(trifluoromethyl)phenyl)urea 
• 1347008-70-1 1-(2-chloro-4-(2-(5-(trifluoromethyl)-1H-imidazol-2-yl)pyridin-4-yloxy)phenyl)-3-(3,4-dichlorophenyl)urea 
• 1347008-75-6 1-(2-chloro-4-(2-(5-(trifluoromethyl)-1H-imidazol-2-yl)pyridin-4-yloxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea 
• 1347008-77-8 1-(2-chloro-4-(2-(5-(trifluoromethyl)-1H-imidazol-2-yl)pyridin-4-yloxy)phenyl)-3-(3,4,5-trimethoxyphenyl)urea 
• 1347008-91-6 C₁₇H₁₂ClF₃N₄O₂ 

Relevant academic research and scientific papers

Design, synthesis and antitumor activities of novel bis-aryl ureas derivatives as Raf kinase inhibitors

A series of novel bis-aryl ureas containing trifluoromethyl imidazolyl group targeting Raf kinase were designed and synthesized based on the lead compound of Sorafenib. All the prepared compounds were evaluated for their in vitro antiproliferative activities against three human cancer cell lines including MDA-MB-231 (breast), BGC-823 (gastric), and SMMC-7721 (liver). Several compounds from the series exhibited excellent antitumor activities against all three tested cancer lines. Further their inhibitory activities against Raf kinase were investigated, and three compounds (11c, 11d, and 11p) demonstrated better activities than contrast drug Sorafenib. Especially compound 11c was found to be a potent and selective Raf kinase inhibitor and could be considered as a candidate compound for further development.