134701-95-4Relevant academic research and scientific papers
CoA-IT and PAF inhibitors
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, (2008/06/13)
Coenzyme A-independent transacylase is required for the release of free arachidonic acid, and the production of arachidonic acid metabolites and platelet activation factor. Blocking of this enzyme inhibits the production of these inflammatory mediators and will be of therapeutic utility in a broad range of allergic and inflammatory diseases and disorders. Compounds are described herein which inhibit the action of CoA-IT and are therefore useful in the treatment of disease states caused thereby.
Structure-Activity Relationships Associated with 3,4,5-Triphenyl-1H-pyrazole-1-nonanoic Acid, a Nonprostanoid Prostacyclin Mimetic
Meanwell, Nicholas A.,Rosenfeld, Michael J.,Wright, J. J. Kim,Brassard, Catherine L.,Buchanan, John O.,et al.
, p. 389 - 397 (2007/10/02)
A series of phenylated pyrazoloalkanoic acid derivatives were synthesized and evaluated as inhibitors of ADP-induced human platelet aggregation. 3,4,5-Triphenyl-1H-pyrazole-1-nonanoic acid (8d), with an IC50 of 0.4 μM, was the most potent inhibitor identi
