13472-85-0

Basic information

• Product Name: 5-Bromo-2-methoxypyridine
• Synonyms: 2-METHOXY-5-BROMOPYRIDINE 5-BROMO-2-METHOXY-PYRIDINE;5-Bromo-2-methoxypyridine 95%;5-Bromo-2-methoxypyridine ,98%;5-Bromo-2-methoxypyridine,97%;(E)-N-(pyridin-3-ylmethylene)methanamine;5-Bromo-2-methoxypyr;5-BroMo-2-Methoxypyridine, 97% 5ML;2-Methoxy -5-pyridyl broMide
• CAS NO: 13472-85-0
• Molecular Formula: C₆H₆BrNO
• Molecular Weight: 188.02
• EINECS: -0
• Product Categories: Pyridine Series;Pyridines, Pyrimidines, Purines and Pteredines;Pyridines derivates;Alkoxy;Organohalides;Anisoles, Alkyloxy Compounds & Phenylacetates;Bromine Compounds;Miscellaneous Compounds;Bromopyridines;Halopyridines;Boronic Acid;C6Heterocyclic Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Brominated heterocyclic series;alkyl bromide;compounds of pyridine;blocks;Bromides;Pyridines;Pyridine;pyridine derivative
• Mol File: 13472-85-0.mol
• Article Data: 67

Chemical Properties

• Melting Point: 80°C (12 mmHg)
• Boiling Point: 80 °C12 mm Hg(lit.)
• Flash Point: 205 °F
• Appearance: Clear colorless to slightly yellow/Liquid
• Density: 1.453 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.545mmHg at 25°C
• Refractive Index: n20/D 1.555(lit.)
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 1.04±0.10(Predicted)
• BRN: 115150
• CAS DataBase Reference: 5-Bromo-2-methoxypyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Bromo-2-methoxypyridine(13472-85-0)
• EPA Substance Registry System: 5-Bromo-2-methoxypyridine(13472-85-0)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 26-36-36/37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 13472-85-0(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow liquid

Uses

Different sources of media describe the Uses of 13472-85-0 differently. You can refer to the following data:
1. A building block for the β-alanine moiety of an αvβ3 antagonist and for the synthesis of a potent and selective somatostatin sst3 receptor antagonist.
2. 5-Bromo-2-methoxypyridine is used as a ligand for central nicotinic acetylcholine receptor. Also used in a novel synthetic approach to anti-HIV active integrase inhibitors.

InChI:InChI=1/C6H6BrNO/c1-9-6-3-2-5(7)4-8-6/h2-4H,1H3

Upstream product

• 1628-89-3 2-methoxypyridine 
• 624-28-2 2,5-dibromopyridine 
• 124-41-4 sodium methylate 
• 1072-97-5 5-bromo-2-pyridylamine 
• 149-73-5 trimethyl orthoformate 
• 223463-13-6 2-iodo-5-bromopyridine 
• 67-56-1 methanol 
• 39856-50-3 5-bromo2-nitropyridine 
• 53939-30-3 5-bromo-2-chloropyridine 
• 34851-41-7 tetrabutyl ammonium methoxide 
• 6628-77-9 6-methoxy-pyridin-3-ylamine 
• 13466-38-1 5-bromopyridin-2(1H)-one 
• 74-88-4 methyl iodide 

Downstream Products

• 221215-59-4 1-(2-methoxy-5-pyridyl)-2-cyclohexenol 
• 1628-89-3 2-methoxypyridine 
• 380224-11-3 5-(triethoxysilyl)-2-methoxypyridine 
• 51834-97-0 6-methoxypyridine-3-ol 
• 163105-89-3 2-methoxy-pyridine-5-boronic acid 
• 13472-56-5 2-methoxy-5-methylpyridine 
• 32401-36-8 (6-methoxypyridin-3-yl)(phenyl)methanone 
• 329974-16-5 (Z)-3-(6-methoxy-3-pyridyl)acrylonitrile 
• 329974-16-5 (E)-3-(6-methoxy-3-pyridyl)acrylonitrile 
• 484673-50-9 2-methoxy-5-(1-trityl-1H-imidazol-4-yl)-pyridine 
• 1010074-95-9 methyl 4-[(6-methoxypyridin-3-yl)oxy]benzoate 
• 1010074-99-3 3-(6-methoxy-pyridin-3-yloxy)-benzoic acid ethyl ester 
• 850141-84-3 4-(2-methoxy-5-pyridinyl)-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester 
• 1011797-10-6 2-methoxy-5-(2-methyl-3-nitrophenyl)pyridine 

Relevant articles and documents

Preparation method of ortho-alkoxy substituted pyridine compound

The invention provides a preparation method of an ortho-alkoxy substituted pyridine compound, the preparation method comprises the following step: reacting an ortho-amino substituted pyridine compound with an ortho-formate compound in the presence of a nitrite compound to generate the ortho-alkoxy substituted pyridine compound. The method has the advantages of high efficiency, low cost, environmental protection and the like.

Preparation method of 2,5-dimethoxy pyridine

The invention discloses a preparation method of 2,5-dimethoxy pyridine, and belongs to the technical field of medicine synthesis. The method comprises the following steps that 1, under the existence of an alcohol solvent, a compound shown as a formula A and sodium methoxide take contact reaction to form a compound shown as a formula B; 2, under the existence of metal catalysts, the compound shownas a formula B in the first step reacts to obtain 2,5-dimethoxy pyridine; aftertreatment and purification are performed to obtain the product. The method has the advantages that the route is short; the steps are few; expensive palladium catalysts and boracic acid catalysts are not used; the equipment cost is reduced; the use of flammable and explosive lithium reagents and peroxide is avoided; thereaction conditions are mild; the aftertreatment operation is simple and convenient; the total yield and the purity are improved; the product quality can be easily controlled; the industrial amplification prospects are good.

Novel synthesis method for ortho-alkane superseded pyridine

The invention relates to a novel synthesis method for ortho-alkane superseded pyridine. According to the method, ortho halogenated pyridine serves as raw materials, the ortho halogenated pyridine and corresponding alcohol react to obtain the ortho-alkane superseded pyridine under the action of sodium hydroxide. The reaction has universality for the ortho halogenated pyridine, and the method is simple and practical. Influence of consumption of the sodium hydroxide on mono-substitution and di-substitution in the reaction is inspected, alkoxy mono-substitution products and alkoxy di-substitution production are acquired, and a novel simply-operated, economical and favorable process for synthesis ortho-alkane superseded pyridine is provided.