13475-69-9Relevant academic research and scientific papers
Synthesis, antifungal activity and structure-activity relationships of novel 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid amides
Du, Shijie,Tian, Zaimin,Yang, Dongyan,Li, Xiuyun,Li, Hong,Jia, Changqing,Che, Chuanliang,Wang, Mian,Qin, Zhaohai
, p. 8395 - 8408 (2015)
A series of novel 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid amides were synthesized and their activities were tested against seven phytopathogenic fungi by an in vitro mycelia growth inhibition assay. Most of them displayed moderate to excellent activities. Among them N-(2-(5-bromo-1H-indazol-1-yl)phenyl)-3-(difluoro-methyl)-1-methyl-1H-pyrazole-4-carboxamide (9m) exhibited higher antifungal activity against the seven phytopathogenic fungi than boscalid. Topomer CoMFA was employed to develop a three-dimensional quantitative structure-activity relationship model for the compounds. In molecular docking, the carbonyl oxygen atom of 9m could form hydrogen bonds towards the hydroxyl of TYR58 and TRP173 on SDH.
Ce(SO4)2-mediated nitration of N,N-dialkylanilines with NaNO2 in water
Yang, Xianghua,Xi, Chanjuan
, p. 3381 - 3392 (2008/02/12)
Ce(SO4)2-mediated nitration of N,N-dialkylanilines with NaNO2 using water as the solvent has been achieved in good to excellent yields. The nitrating reaction proceeded smoothly at ambient temperature. Copyright Taylor & Francis Group, LLC.
