1347747-95-8Relevant academic research and scientific papers
An efficient catalytic method for the Friedl?nder annulation mediated by peptide coupling agent propylphosphonic anhydride (T3P)
Augustine, John Kallikat,Bombrun, Agnes,Venkatachaliah, Srinivasa
, p. 6814 - 6818 (2011)
We have demonstrated the utilization of T3P, a mild and low toxic peptide coupling agent, as a promoter and water scavenger in the Friedl?nder annulation, and thus introduced a highly efficient catalytic process to access carbocyclic and heterocyclic fused quinolines under microwave irradiation or a conventional heating technique. The reaction conditions are sufficiently mild to tolerate the acid and base sensitive functional groups that can serve as levers for further extension of the quinoline products.
