134778-32-8

Basic information

• Product Name: 2-t-butyl-4-(ethoxymethyl)-2-methylphenol
• Synonyms: 2-t-butyl-4-(ethoxymethyl)-2-methylphenol
• CAS NO: 134778-32-8
• Molecular Weight: 222.327
• Mol File: 134778-32-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-t-butyl-4-(ethoxymethyl)-2-methylphenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-t-butyl-4-(ethoxymethyl)-2-methylphenol(134778-32-8)
• EPA Substance Registry System: 2-t-butyl-4-(ethoxymethyl)-2-methylphenol(134778-32-8)

Safety Data

• Hazardous Substances Data: 134778-32-8(Hazardous Substances Data)

Upstream product

• 64-17-5 ethanol 
• 1879-09-0 2,4-dimethyl-6-tert-butylphenol 

Relevant articles and documents

The Oxidation of 2,4,6-Trimethylphenol with Molecular Oxygen Catalyzed by a Copper(II)-Oxime or Copper(II)-Amine System

2,4,6-Trimethylphenol (1a) was selectively oxidized to 3,5-dimethyl-4-hydroxybenzaldehyde (2a) by molecular oxygen in the presence of a copper(II) chloride-oxime or copper(II) chloride-amine catalyst in alcohol at ambient temperature.When an acid was present in the catalyst system, the formation of both 2,6-dimethyl-p-benzoquinone (3) and a formaldehyde dialkyl acetal was accelerated.It is likely that 2a is produced by way of the formation of a quinonemethide intermediate, followed by a repeated 1,6-addition of alcohol on the intermediate to form a 4-(alkoxymethyl)-2,6-dimethylphenol (5a), and then 3,5-dimethyl-4-hydroxybenzaldehyde dialkyl acetal, which would be hydrolyzed to 2a.When the reaction time was shortened, 5a was isolated in good yield.Oxidations of the other p-methyl-substituted phenols were also examined using the present oxidation system.