13479-38-4

Basic information

• Product Name: (11beta)-11,21-dihydroxypregna-1,4-diene-3,20-dione
• Synonyms: pregna-1,4-diene-3,20-dione, 11,21-dihydroxy-, (11beta)-
• CAS NO: 13479-38-4
• Molecular Formula: C₂₁H₂₈O₄
• Molecular Weight: 344.4446
• Mol File: 13479-38-4.mol

Chemical Properties

• Boiling Point: 532.789°C at 760 mmHg
• Flash Point: 290.094°C
• Density: 1.241g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.592
• CAS DataBase Reference: (11beta)-11,21-dihydroxypregna-1,4-diene-3,20-dione(CAS DataBase Reference)
• NIST Chemistry Reference: (11beta)-11,21-dihydroxypregna-1,4-diene-3,20-dione(13479-38-4)
• EPA Substance Registry System: (11beta)-11,21-dihydroxypregna-1,4-diene-3,20-dione(13479-38-4)

Safety Data

• Hazardous Substances Data: 13479-38-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(11beta)-11,21-dihydroxypregna-1,4-diene-3,20-dione is used as an anti-inflammatory and immunosuppressive agent for the treatment of various medical conditions, such as inflammation, allergic reactions, and certain types of cancer. Its potent anti-inflammatory effects help alleviate symptoms and improve overall health.
Used in Inflammatory Conditions:
(11beta)-11,21-dihydroxypregna-1,4-diene-3,20-dione is used as a medication to reduce inflammation in various conditions, such as rheumatoid arthritis, lupus, and asthma. Its ability to suppress the immune system helps control the body's inflammatory response and provide relief from symptoms.
Used in Allergic Reactions:
(11beta)-11,21-dihydroxypregna-1,4-diene-3,20-dione is used as an anti-allergic medication to treat severe allergic reactions and conditions, such as anaphylaxis and severe asthma. Its immunosuppressive properties help reduce the body's allergic response and provide relief from symptoms.
Used in Cancer Treatment:
(11beta)-11,21-dihydroxypregna-1,4-diene-3,20-dione is used as a medication in the treatment of certain types of cancer, such as brain tumors and leukemia. Its anti-inflammatory and immunosuppressive effects can help manage symptoms and improve the effectiveness of other cancer treatments.
Used in Ophthalmology:
(11beta)-11,21-dihydroxypregna-1,4-diene-3,20-dione is used as an eye drop to treat eye inflammation and conditions such as uveitis and iritis. Its anti-inflammatory properties help reduce inflammation and alleviate symptoms in the eye.

Upstream product

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• 75448-51-0 (10R,11S,13S,17S)-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylic acid 
• 50-22-6 Corticosterone 

Relevant articles and documents

Cytotoxic nucleoside-corticosteroid phosphodiesters

Nucleotides of nucleosides or bases having known cytotoxic activity are reacted with steroids, preferably corticosteroids, to form corresponding cytotoxic nucleoside-corticosteroid phosphodiester analogues of the formula: STR1 wherein: steroid is the residue formed by removal of a hydroxyl hydrogen atom from a natural or synthetic adrenal corticosteroid containing the characteristic cyclopentanophenanthrene nucleus which is esterified to the phosphate moiety at the 21-position; sugar is a naturally occurring pentose or deoxypentose in the furanose form, preferably ribose, deoxyribose, lyxose, xylose or arabinose and especially ribose, deoxyribose or arabinose, which is esterified to the phosphate moiety at the 5'-position and covalently bonded to the heterocycle moiety at the 1'-position to form a nucleoside; and heterocycle is a purine, pyrimidine, hydrogenated pyrimidine, triazolopurine or similar nucleoside base. The conjugates exhibit an enhanced therapeutic index as compared to the parent nucleoside or base compounds, and are thus useful cytotoxic, antiviral and antineoplastic agents.