13480-36-9

Basic information

• Product Name: MIDA anhydride
• Synonyms: 4-Methylmorpholine-2,6-dione;MIDA anhydride;4-Methylmorpholine-2,6-dione 97%;4-methyl-2,6-Morpholinedione;(N-methylimino)diacetic acid anhydride
• CAS NO: 13480-36-9
• Molecular Formula: C₅H₇NO₃
• Molecular Weight: 129.11398
• Mol File: 13480-36-9.mol
• Article Data: 9

Chemical Properties

• Melting Point: 41-45°C
• Boiling Point: 252.5±33.0 °C(Predicted)
• Flash Point: >110℃
• Appearance: /
• Density: 1.271±0.06 g/cm3(Predicted)
• PKA: 3.35±0.20(Predicted)
• CAS DataBase Reference: MIDA anhydride(CAS DataBase Reference)
• NIST Chemistry Reference: MIDA anhydride(13480-36-9)
• EPA Substance Registry System: MIDA anhydride(13480-36-9)

Safety Data

• Hazard Codes: Xn
• Statements: 22-41
• Safety Statements: 26-39
• WGK Germany: 1
• Hazardous Substances Data: 13480-36-9(Hazardous Substances Data)

Usage

General Description

MIDA anhydride, also known as N-methyliminodiacetic anhydride, is a chemical compound commonly used as a reagent in organic synthesis. It is a versatile building block that can be used in the synthesis of a wide range of complex organic molecules. MIDA anhydride is particularly useful for the preparation of MIDA boronates, which are valuable intermediates for the synthesis of pharmaceuticals, agrochemicals, and materials. MIDA anhydride has also found applications in the field of coordination chemistry and metal-catalyzed coupling reactions. MIDA anhydride is valued for its stability, ease of handling, and high efficiency in organic transformations, making it a valuable tool for synthetic chemists.

Upstream product

• 4408-64-4 N-methyliminodiacetic acid 
• 108-24-7 acetic anhydride 

Downstream Products

• 1104637-03-7 C₁₀H₁₀BNO₆ 
• 1565829-30-2 phenethyl MIDA boronate 
• 1072960-66-7 4-formylphenylboronic acid 
• 1104637-53-7 B-ethynyl N-methyliminodiacetic acid boronate 

Relevant articles and documents

A Mild Method for Making MIDA Boronates

We disclose that a predried form of methyliminodiacetic acid (MIDA), MIDA anhydride, acts as both a source of the MIDA ligand and an in situ desiccant to enable a mild and simple MIDA boronate synthesis procedure. This method expands the range of sensitive boronic acids that can be converted into their MIDA boronate counterparts. Further utilizing unique properties of MIDA boronates, we have developed a MIDA Boronate Maker Kit which enables the direct preparation and purification of MIDA boronates from boronic acids using only heating and centrifuge equipment that is widely available in laboratories that do not specialize in organic synthesis.

Identification of novel quinazolinedione derivatives as RORγt inverse agonist

Novel small molecules were synthesized and evaluated as retinoic acid receptor-related orphan receptor-gamma t (RORγt) inverse agonists for the treatment of inflammatory and autoimmune diseases. A hit compound, 1, was discovered by high-throughput screeni

CONDENSED HETEROCYCLIC COMPOUND

The present invention provides a fused heterocyclic compound having an RORγt inhibitory action. The present invention relates to a compound represented by the formula (I'): wherein each symbol is as defined in the specification, provided that 2-(2-((4-cyanophenyl)amino)-2-oxoethoxy)-N-(9-ethyl-9H-carbazol-3-yl)acetamide and N-(4-cyanophenyl)-N'-(9-ethyl-9H-carbazol-3-yl)-3-methylpentanediamide are excluded, or a salt thereof.