1348034-59-2

Upstream product

• 22248-14-2 6-hydroxy-2,3,4-trimethoxyacetophenone 
• 642-71-7 3,4,5-trimethoxyphenol 
• 35418-05-4 (E)-3-nitrocinnamic acid chloride 
• 555-68-0 (E)-3-Nitrocinnamic acid 

Downstream Products

• 1467668-53-6 2-(3-aminophenyl)-5,6,7-trimethoxy-4H-chromen-4-one 

Relevant academic research and scientific papers

Natural products hybrids: 3,5,4′-Trimethoxystilbene-5,6,7-trimethoxyflavone chimeric analogs as potential cytotoxic agents against diverse human cancer cells

Cancer still represents a major global health problem. All currently available anticancer agents have disadvantages like resistance or side effects. Therefore, introduction of novel anticancer agents is needed. Intrigued by the high success rate for natural products-based drug discovery, we designed and synthesized antiproliferative chemical entities as hybrids of two natural products; 3,5,4′-trimethoxystilbene and 5,6,7-trimethoxyflavone. To probe the spectrum of the synthesized compounds, in vitro evaluation was conducted against nine panels representing major cancer diseases. The results revealed the hybrid analogs 4f, 4h, 4k and 4q as promising broad-spectrum anticancer lead compounds eliciting high growth inhibition of several cell lines representing multiple cancers diseases. Evaluation of the promising lead compounds against normal human cell lines suggested a selective cytotoxic effect on cancer cells. Mechanistic investigation of the cytotoxic activity of compound 4f in human cervical cancer HeLa cells showed that it triggers cell death through induction of apoptosis. As a whole, this study presents the natural products hybrid analogs 4f, 4h, 4k and 4q as potential lead compounds for further development of novel anticancer therapeutics.

Flavone Derivatives and Anti-Cancer Agents Comprising the Same

Provided in the present invention is a flavon derivative having excellent anti-cancer activity, a manufacturing method thereof, and an anti-cancer composition including the same as an active component.