134807-28-6

Basic information

• Product Name: N-BOC-2-AMINOMETHYLPYRIDINE 97
• Synonyms: N-BOC-2-AMINOMETHYLPYRIDINE 97;Carbamic acid, (2-pyridinylmethyl)-, 1,1-dimethylethyl ester (9CI);N-Boc-2-aminomethylpyridine,N-(tert-Butoxycarbonyl)-2-aminomethylpyridine;tert-butyl pyridin-2-ylMethylcarbaMate;N-(2-Pyridinylmethyl)-Carbamic Acid 1,1-Dimethylethyl Ester;Tert-Butyl N-(PyridiN-2-Ylmethyl)Carbamate
• CAS NO: 134807-28-6
• Molecular Formula: C₁₁H₁₆N₂O₂
• Molecular Weight: 208.25694
• Product Categories: N-BOC;Heterocyclic Compounds
• Mol File: 134807-28-6.mol
• Article Data: 20

Chemical Properties

• Boiling Point: 330 °C at 760 mmHg
• Flash Point: >230 °F
• Appearance: /
• Density: 1.0699 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.000171mmHg at 25°C
• Refractive Index: n20/D 1.5020(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: N-BOC-2-AMINOMETHYLPYRIDINE 97(CAS DataBase Reference)
• NIST Chemistry Reference: N-BOC-2-AMINOMETHYLPYRIDINE 97(134807-28-6)
• EPA Substance Registry System: N-BOC-2-AMINOMETHYLPYRIDINE 97(134807-28-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38-43
• Safety Statements: 26-36/37
• WGK Germany: 3
• Hazardous Substances Data: 134807-28-6(Hazardous Substances Data)

Usage

General Description

N-BOC-2-aminomethylpyridine 97 is a chemical compound that consists of a BOC-protected amine group attached to a pyridine ring. The BOC (tert-butoxycarbonyl) protecting group is commonly used in organic synthesis to mask reactive amine groups, allowing for selective reactions and controlled release of the amine functionality. N-BOC-2-AMINOMETHYLPYRIDINE 97 is often used as a building block in the synthesis of pharmaceuticals, agrochemicals, and materials. It is a versatile intermediate that can undergo various chemical transformations to yield a wide range of derivatives with different functional groups, making it a valuable tool in organic chemistry research and development. The "97" in the name indicates the high purity of the compound, which is important for its use in sensitive and precise chemical reactions.

InChI:InChI=1/C11H16N2O2/c1-11(2,3)15-10(14)13-8-9-6-4-5-7-12-9/h4-7H,8H2,1-3H3,(H,13,14)

Upstream product

• 3731-51-9 2-(Aminomethyl)pyridine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1282034-09-6 2-pyridyl dimethylsulfamate 
• 1314538-55-0 potassium tert-butyl N-[(trifluorolambda-4-boranyl)methyl]carbamate 
• 109-09-1 2-chloropyridine 

Downstream Products

• 370594-54-0 methyl 4-{[{[t-butyloxy]carbonyl}(2-pyridinylmethyl)amino]methyl}benzoate 
• 1443117-92-7 C₁₈H₂₃N₂O₂⁽¹⁺⁾*Br^(1-) 
• 1260842-85-0 tert-butyl ((1-benzylpiperidin-2-yl)methyl)carbamate 
• 150099-69-7 prop-2-ynyl-pyridin-2-ylmethylamine 
• 501375-90-2 N-methyl-N-[6-(4-oxo-4H-1,3-benzothiazin-2-yl)-2-pyridyl]cyclohexanecarboxamide 
• 501376-87-0 N-[[6-(4-Oxo-4H-1,3-benzothiazin-2-yl)-2-pyridyl]methyl]benzenesulfonamide 
• 501376-81-4 N-[[6-(4-Oxo-4H-1,3-benzothiazin-2-yl)-2-pyridyl]methyl]benzamide 
• 501375-88-8 N-Methyl-N-[6-(4-oxo-4H-1,3-benzothiazin-2-yl)-2-pyridyl]benzamide 
• 1449334-66-0 tert-butyl 2-hydroxy-2-(4-methoxyphenyl)-1-(pyridin-2-yl)ethylcarbamate 
• 1449334-64-8 tert-butyl (1-hydroxycyclohexyl)(pyridin-2-yl)methylcarbamate 
• 1449334-60-4 tert-butyl 2-hydroxy-2,2-diphenyl-1-(pyridin-2-yl)ethylcarbamate 
• 139004-99-2 (S)-2,6-Diamino-hexanoic acid (1-tridecanoyl-piperidin-2-ylmethyl)-amide; hydrochloride 
• 139004-99-2 (R)-2,6-Diamino-hexanoic acid (1-tridecanoyl-piperidin-2-ylmethyl)-amide; hydrochloride 
• 141774-30-3 (S)-2-Amino-3-phenyl-N-(1-tridecanoyl-piperidin-2-ylmethyl)-propionamide; hydrochloride 

Relevant articles and documents

A Click procedure with heterogeneous copper to tether technetium-99m chelating agents and rhenium complexes. Evaluation of the chelating properties and biodistribution of the new radiolabelled glucose conjugates

An efficient protocol was developed to tether chelating agents and rhenium complexes onto a glucoside scaffold with a heterogeneous copper catalyst via click chemistry. The supported catalyst avoids the formation of unwanted copper complexes during the cyclisation step. The possibility to graft a pre-chelated M(CO)3 core by click chemistry onto a biomolecule was highlighted for the first time. 99mTc(CO)3-glucoconjugates displayed excellent in vitro stability, a fast in vivo blood clearance and a low specific organ uptake or long-term retention in spleen and stomach.

Nanoceria as an efficient and green catalyst for the chemoselective N-tert-butyloxycarbonylation of amines under the solvent-free conditions

Nanocerium oxide mediated an efficient and green protocol has been described for the chemoselective N-tert-butyloxycarbonylation of amines under the solvent-free conditions at ambient temperature. Various aliphatic, aromatic and heteroaromatic amines were protected using developed protocol and several functional groups such as alcohol, phenol and ester were well tolerated under these conditions. The rapid reaction rate, mild conditions, very good functional group tolerance, excellent yield, solvent-free, easy recovery products and excellent catalyst recyclability are the advantages of this protocol. This makes the protocol feasible, economical and environmentally benign.

Metal-Free C-C Coupling of an Allenyl Sulfone with Picolyl Amides to Access Vinyl Sulfones via Pyridine-Initiated in Situ Generation of Sulfinate Anion

Vinyl sulfones are privileged motifs known for their biological activity and synthetic utility. Synthetic transformations to efficiently access high-value compounds with these motifs are desired and sought after. Herein, a new procedure is described to fo

Chemoselective: N-tert -butyloxycarbonylation of amines in glycerol

A catalyst-free, efficient and green protocol has been developed for the chemoselective N-Boc protection of amines by using glycerol as a solvent at room temperature. A variety of functionalized amines, such as aliphatic, aromatic as well as heteroaromatic were protected using the developed protocol. N-tert-Butyloxycarbonylation derivatives were formed without the formation of isocyanate, urea, N,N-di-t-Boc, or oxazolidinone as side products. The operational simplicity, cleaner reaction, rapid reaction convergence, functional group tolerance, excellent yield, high selectivity, catalyst-free feature and solvent recyclability are the distinct advantages of this protocol. Owing to these merits, this protocol is feasible, economical and environmentally benign.