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Usage

Uses

Used in Pharmaceutical Industry:
2-[(2,3-dimethylphenyl)amino]benzonitrile is used as a building block for the synthesis of various pharmaceuticals and organic compounds. Its unique structure and chemical properties contribute to the development of new drugs and therapeutic agents.
Used in Research and Development:
In the field of research and development, 2-[(2,3-dimethylphenyl)amino]benzonitrile is used as a reagent in organic synthesis. It aids in the creation of novel compounds and contributes to the advancement of scientific knowledge in organic chemistry.
Used in Materials Science:
2-[(2,3-dimethylphenyl)amino]benzonitrile is also utilized in materials science for the production of various compounds with specific properties. Its versatility and reactivity make it a valuable component in the development of new materials with potential applications in various industries.

Upstream product

• 873-32-5 2-Chlorobenzonitrile 
• 87-59-2 2,3-Dimethylaniline 
• 55591-34-9 N-(2,3-dimethylphenyl)cyanamide 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 612-24-8 o-nitrobenzonitrile 
• 183158-34-1 2,3-dimethylphenylboronic acid 
• 13481-66-8 N-<2,3-Dimethyl-phenyl>-anthranilsaeure-amid 

Downstream Products

• 61-68-7 mefenamic Acid 

Relevant academic research and scientific papers

Visible-Light- And PPh3-Mediated Direct C-N Coupling of Nitroarenes and Boronic Acids at Ambient Temperature

We present here a metal-free, visible-light- and triphenylphosphine-mediated intermolecular, reductive amination between nitroarenes and boronic acids at ambient temperature without any photocatalyst. Mechanistically, a slow reduction of nitroarenes to a nitroso and, finally, a nitrene intermediate occurs that leads to the amination product with concomitant 1,2-aryl/-alkyl migration from a boronate complex. A wide range of nitroarenes underwent C-N coupling with aryl-/alkylboronic acids providing high yields.

Intermolecular Reductive C-N Cross Coupling of Nitroarenes and Boronic Acids by PIII/PV=O Catalysis

A main group-catalyzed method for the synthesis of aryl- and heteroarylamines by intermolecular C-N coupling is reported. The method employs a small-ring organophosphorus-based catalyst (1,2,2,3,4,4-hexamethylphosphetane) and a terminal hydrosilane reductant (phenylsilane) to drive reductive intermolecular coupling of nitro(hetero)arenes with boronic acids. Applications to the construction of both Csp2-N (from arylboronic acids) and Csp3-N bonds (from alkylboronic acids) are demonstrated; the reaction is stereospecific with respect to Csp3-N bond formation. The method constitutes a new route from readily available building blocks to valuable nitrogen-containing products with complementarity in both scope and chemoselectivity to existing catalytic C-N coupling methods.

Aminocyanation by the addition of N-CN bonds to arynes: Chemoselective synthesis of 1,2-bifunctional aminobenzonitriles

An efficient aminocyanation by the direct addition of aryl cyanamides to arynes is described, enabling incorporation of highly useful amino and cyano groups synchronously via cleavage of inert N-CN bonds, affording synthetically useful 1,2-bifunctional aminobenzonitriles. The postsynthetic functionalization of the aminocyanation products allows diverse formation of synthetically important derivatives such as drug molecule Ponstan and fused heterocycles.

A highly efficient precatalyst for amination of aryl chlorides: Synthesis, structure and application of a robust acenaphthoimidazolylidene palladium complex

A robust palladium NHC complex was synthesized and exhibits exceptional activity and selectivity as a precatalyst in the amination of aryl chlorides and tolerates a wide range of substrates at low catalyst loadings.