134821-75-3

Upstream product

• 58479-61-1 tert-butylchlorodiphenylsilane 
• 1463-10-1 5-Methyluridine 
• 214039-19-7 (S)-2',3'-O-(2-bromo-1-diethylphosphonoethylidene)-5'-O-tert-butyldiphenylsilyl-5-methyluridine 

Downstream Products

• 1572186-26-5 C₂₈H₃₂N₂O₇Si 
• 1572186-29-8 C₃₂H₄₃N₂O₁₀PSi 
• 1572186-33-4 C₃₂H₄₃N₂O₉PSi 
• 1572186-23-2 C₂₉H₃₄N₂O₆Si 
• 317820-42-1 5'-O-(tert-butyldiphenylsilyl)-2'-O-[2-[(N,N-diethylamino)oxy]ethyl]-5-methyluridine 
• 317820-41-0 5'-O-tert-butyldiphenlsilyl-2'-O-[2-(acetaldoximinooxy)ethyl]-5-methyluridine 
• 212061-25-1 5'-O-(tert-butyldiphenylsilyl)-2'-O-[2-[(2,3-dihydro-1,3-dioxo-1H-isoindol-2-yl)oxy]ethyl]-5-methyluridine 
• 212061-24-0 5'-O-(tert-butyldiphenylsilyl)-2'-O-(2-hydroxyethyl)-5-methyluridine 
• 1415645-49-6 7-O-(tert-butyldiphenylsilyl)morpholinothymidine 
• 1415645-54-3 7-O-(tert-butyldiphenylsilyl)-N-trityl morpholinothymidine 
• 914361-76-5 1-((2R,6S)-6-(hydroxymethyl)-4-tritylmorpholin-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione 

Relevant academic research and scientific papers

Synthesis and in vitro growth inhibitory activity of novel silyl- and trityl-modified nucleosides

Seventeen silyl- and trityl-modified (5′-O- and 3′,5′-di-O-) nucleosides were synthesized with the aim of investigating the in vitro antiproliferative activities of these nucleoside derivatives. A subset of the compounds was evaluated at a fixed concentra

Improved protocol for the synthesis of flexibly protected morpholino monomers from unprotected ribonucleosides

An inexpensive and much improved protocol has been developed for the synthesis of protected morpholino monomers from unprotected ribonucleosides in high overall yield, using oxidative glycol cleavage and reductive amination strategy. Unlike the previous methods, the present strategy allows installing the exocyclic amine protections at a later stage, and thus avoids the use of expensive, or commercially unavailable, exocyclic amine-protected ribonucleosides as starting materials. To demonstrate the flexibility of the present method in choosing protecting groups, the monomers have been protected with several such groups of different deblocking properties at the exocyclic amine position.

MORPHOLINO-BASED ANTISENSE AGENT

Morpholino-based oligomers suitable as antisense agent comprising modifications of phosphorodiamidate backbone or modification with 5-substituted pyrimidines of morpholino compound that is soluble in culture medium and sufficient for cell penetration thereby eliminating the need for injecting into the cells. Monomers comprising the said oligomers and its method of manufacture, method of manufacture of the said oligomers and its dye, flurophore, drug, biomolecule conjugate wherein the said oligomers find different end use but not limited to regulation of gene expression, tissue culture with improved transfection efficiency and related studies on cellular transfection.

Modulation of diacylglycerol acyltransferase 1 expression

Compounds, compositions and methods are provided for modulating the expression of diacylglycerol acyltransferase 1. The compositions comprise oligonucleotides, targeted to nucleic acid encoding diacylglycerol acyltransferase 1. Methods of using these compounds for modulation of diacylglycerol acyltransferase 1 expression and for diagnosis and treatment of disease associated with expression of diacylglycerol acyltransferase 1 are provided.

2',3'-O-phosphonoalkylidene derivatives of ribonucleosides: Synthesis and reactivity

A novel type of nucleotide analogues, the 2',3'-O-(1- diethylphosphono)alkylidene derivatives of ribonucleosides was prepared by redox reaction of diethyl chlorophosphite with various nucleoside orthoesters. Some of these compounds undergo interesting rearrangements when treated with nucleophiles. The configuration of the title compounds was determined by 2D-ROESY experiments. Biological activity of partially protected nucleotide analogues is also discussed.