13483-18-6

Basic information

• Product Name: 1,2-bis(chloromethoxy)ethane
• Synonyms: 1,2-bis(chloromethoxy)ethane;BIS-1,2(CHLOROMETHOXY)ETHANE;Ethylene glycol bis(chloromethyl) ether;1,2-bis(ChloroMethoxy)ethane (90%)
• CAS NO: 13483-18-6
• Molecular Formula: C₄H₈Cl₂O₂
• Molecular Weight: 159.01112
• EINECS: 236-791-6
• Mol File: 13483-18-6.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 221.93°C (rough estimate)
• Flash Point: 71.6°C
• Appearance: /
• Density: 1.3421 (rough estimate)
• Vapor Pressure: 0.89mmHg at 25°C
• Refractive Index: 1.4386 (estimate)
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform (Slightly), Dichloromethane (Slightly), Methanaol (Slightly)
• Stability: Moisture Sensitive
• CAS DataBase Reference: 1,2-bis(chloromethoxy)ethane(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-bis(chloromethoxy)ethane(13483-18-6)
• EPA Substance Registry System: 1,2-bis(chloromethoxy)ethane(13483-18-6)

Safety Data

• Hazardous Substances Data: 13483-18-6(Hazardous Substances Data)

Usage

Chemical Properties

Viscous liquid.

Uses

1,2-bis(Chloromethoxy)ethane is a carcinogenic compound.

Hazard

Questionable carcinogen.

Safety Profile

Questionable carcinogen withexperimental neoplastigenic data. When heated to decomposition it emits toxicfumes of Cl-.

InChI:InChI=1/C4H8Cl2O2/c5-3-7-1-2-8-4-6/h1-4H2

Upstream product

• 50-00-0 formaldehyd 
• 107-21-1 ethylene glycol 
• 7647-01-0 hydrogenchloride 
• 110-88-3 1,3,5-Trioxan 
• 93228-13-8 boric acid tris-(2-chloromethoxy-ethyl) ester 

Downstream Products

• 5732-48-9 1,2-bis-methoxymethoxy-ethane 
• 2568-90-3 di-n-butyloxymethane 
• 5703-97-9 1,2-bis-butoxymethoxy-ethane 
• 7736-68-7 bis-(2-butoxymethoxy-ethyl) ether 
• 18854-56-3 1,2-di-n-propoxyethane 
• 90114-17-3 1,2-bis(acetoxy-methyloxy)ethane 
• 25664-65-7 1,2-Bis-benzyloxymethoxy-aethan 
• 141870-48-6 1,6-bis(diphenylphosphinoyl)-2,5-dioxahexane 
• 40842-04-4 α,ω-bis(O-propargyl)ethylene glycol 
• 117941-41-0 1,1'-bis<4-<(hydroxyimino)methyl>-3-methyl-1H-imidazolium chloride> 
• 93191-06-1 1.2-Bis-cyclohexyloxymethoxy-ethan 
• 61748-82-1 1-{Butyl-[2-(dibutyl-phosphinoylmethoxy)-ethoxymethyl]-phosphinoyl}-butane 
• 94756-88-4 1,2-Bis-(3-phenyl-allyloxy)-ethan 

Relevant articles and documents

New oxime reactivators connected with CH2O(CH2)nOCH2 linker and their reactivation potency for organophosphorus agents-inhibited acetylcholinesterase

New bis-pyridinium oxime reactivators 6 with CH2O(CH2)2OCH2 and CH2O(CH2)4OCH2 linkers between the two pyridinium rings were designed and synthesized. In the in vitro test of their potency to reactivate AChE inhibited by organophosphorus agents at 5 × 10-3 M concentration, the reactivation ability of 1,2-dimethoxy-ethylene-bis-N,N′-4-pyridiumaldoxime dichloride (6a) was 63% for housefly (HF) AChE inhibited by diisopropyl fluorophosphates (DFP), 51% for bovine red blood cell (RBC) AChE inhibited by DFP, 67% for HF-AChE inhibited by paraoxon, and 81% for RBC-AChE inhibited by paraoxon. Except in the case of DFP-inhibited HF AChE test of 2-PAM, the activities of 6a are much higher than the activities of 2-PAM and HI-6 which are AChE reactivators currently in use.

TRINITROETHYL ETHERS OF SUBSTITUTED ALCOHOLS

The influence of the trinitromethane salt cations and the substituents in the alkyl moiety of chloromethyl ethers of alcohols on the yields of trinitroethyl ethers of the substituted alcohols formed from them was established.On this basis a representative series of previously unavailable trinitroethanol ethers was synthesized.

Synthesis of 9,9'-[1,2-Ethanediylbis(oxymethylene)]bis-2-amino- 1,9-dihydro-6H-purin-6-one, an impurity of acyclovir

The synthesis of 9,9'-[1,2-ethanediylbis(oxymethylene)]bis-2-amino-1,9- dihydro- 6H-purin-6-one, a minor impurity of acyclovir, is described. Starting with commercial N-(9-acetyl-6-oxo-1H-purin-2-yl)acetamide, the process uses an acid catalysed phase transfer catalysis (PTC) process to produce the selective alkylation at the 9 position of the guanine ring.

POLYMER COMPOUND, PHOTORESIST COMPOSITION CONTAINING SUCH POLYMER COMPOUND, AND METHOD FOR FORMING RESIST PATTERN

A polymer compound that, within a chemically amplified positive resist system, exhibits a significant change in alkali solubility from a state prior to exposure to that following exposure, as well as a photoresist composition that includes such a polymer compound and a method for forming a resist pattern, which are capable of forming fine patterns with a high level of resolution. The polymer compound includes, as an alkali-soluble group (i), a substituent group in which a group selected from amongst alcoholic hydroxyl groups, carboxyl groups, and phenolic hydroxyl groups is protected with an acid dissociable, dissolution inhibiting group (ii) represented by a general formula (1) shown below: (wherein, A represents an organic group of 1 to 20 carbon atoms with a valency of at least n+1, and n represents an integer from 1 to 4).