134830-17-4

Basic information

• Product Name: (1S,6R,7R)-4-(2'-methoxycarbonylethyl)-3-methyl-7β-phenoxyacetamidoceph-3-em 1-oxide
• CAS NO: 134830-17-4
• Molecular Weight: 406.459
• Mol File: 134830-17-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1S,6R,7R)-4-(2'-methoxycarbonylethyl)-3-methyl-7β-phenoxyacetamidoceph-3-em 1-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,6R,7R)-4-(2'-methoxycarbonylethyl)-3-methyl-7β-phenoxyacetamidoceph-3-em 1-oxide(134830-17-4)
• EPA Substance Registry System: (1S,6R,7R)-4-(2'-methoxycarbonylethyl)-3-methyl-7β-phenoxyacetamidoceph-3-em 1-oxide(134830-17-4)

Safety Data

• Hazardous Substances Data: 134830-17-4(Hazardous Substances Data)

Upstream product

• 10209-10-6 diphenylmethyl (6R,7R)-3-methyl-7β-phenoxyacetamidoceph-3-em-4-carboxylate 
• 134527-23-4 diphenylmethyl (1S,6R,7R)-4-(2'-methoxycarbonylethyl)-3-methyl-7β-phenoxyacetamidoceph-2-em-4-carboxylate 1-oxide 

Downstream Products

• 134830-21-0 (6R,7R)-4-(2'-methoxycarbonylethyl)-3-methyl-7β-phenoxyacetamidoceph-3-em 

Relevant articles and documents

Chemistry of Cephems: C-4 Substitution and Sulphoxide De-oxygenation Reactions.

The anion derived from ceph-3-em esters adds readily to Michael acceptors to give C-4 disubstituted ceph-2-ems.Oxidation of a typical adduct, such as the 4-cyanoethyl-4-diphenylmethyl ester, followed by ester hydrolysis and decarboxylation, gives the 4-cyanoethylceph-3-em sulphoxide which is easily reduced to the sulphide.Furthermore, zinc-acetic acid in DMF (dimethylformamide) is found to be an effective, mild reagent for the de-oxygenation of ceph-2-em sulphoxides.