134832-72-7Relevant academic research and scientific papers
2 - substituent -5 - substituted anilino - 1, 3, 4 - oxdiazole derivatives and its synthetic method and application
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Paragraph 0111-0112, (2017/04/22)
The invention discloses a compound 2-substituent-5-substitued anilino-1,3,4-oxadiazole derivative with functions of resisting plant germs and plant viruses and a preparation method and an application thereof, wherein the structure of the compound is represented by the general formula (I). In the invention, the substituted arylamine is adopted as a start raw material, and a thioether compound is prepared by the steps of esterification, hydrazinolysis, salifying, ring closing and etherification; a sulfone compound is prepared by thioether oxidization. The compound disclosed by the invention has a good inhibiting effect on gibberella zeae, pepper fusarium wilt pathogen, valsa mali and tobacco mosaic virus and can be used for preparing medicines resisting plant germs and plant viruses.
Thiocarbazinic acids: Interaction of carbonoxysulphide with thiosemicarbazides - Synthesis of &β-(thiocarbamyl)thiocarbazinates and 1,3,4-oxadiazole and 1,2,4-triazole derivatives
Chande, Madhukar S.,Karnik, Anil V,Inamdar, Arvind N,Damle, Shruti D
, p. 430 - 432 (2007/10/02)
Interaction of carbon oxysulphide with 4-alkyl/arylthiosemicarbazides (I) in ethanol in the presence of sodium hydroxide forms sodium β-(N-alkyl/arylthiocarbamyl)thiocarbazinates (II).Benzylation of the latter (II) affords 5-alkyl/arylamino-2-benzylmercapto-1,3,4-oxadiazoles (IV), which can also be obtained by a one-pot synthesis involving the reaction of I with carbon oxysulphide in DMF in the presence of triethylamine and benzyl chloride.The syntheses of benzyl β-(N-alkyl/arylthiocarbamyl)thiocarbazinates (III) and 4-aryl-3-mercapto-1,2,4-triazolin-5-ones (VII) are also reported.Some of the compounds exhibit antibacterial activity.
