134836-48-9Relevant academic research and scientific papers
Studies with polyfunctionally substituted heterocycles: Syntheses of polyfunctionally substituted isoquinolines
Elkholy, Yehya M.
, p. 1342 - 1347 (2002)
The three-component reaction of acetaldehyde, cyanothioacetamide, and malononitrile results in 6-amino-3,5-dicyano-4-methylpyridine-2(1H)-thione. The latter reacts with different chemical reagents to afford new substituted isoquinolines and their fused derivatives, which show high fungicidal and bactericidal activities.
Studies with polyfunctionally substituted heterocycles: synthetic approaches to azinylcarbonitrile
Elnagdi, Mohamed Hilmy,Erian, Ayman Wahba
, p. 920 - 924 (2007/10/02)
Mixtures of acetaldehyde and active methylene reagent reacted with cyanothioacetamide to yield thiopyran 4 and pyridine thione 10.The pyridine thione 10 readily reacted with a wide variety of reagents to give novel heterocyclic systems. thiopyran / isoquinoline / enehydrazine / cinnoline
STUDIES WITH POLYFUNCTIONALLY SUBSTITUTED HETEROCYCLES: SYNTHESIS OF NEW THIOPYRANS, PYRIDINES AND PYRANS AND THEIR FUSED DERIVATIVES WITH OTHER RINGS SYSTEMS
Elnagdi, Mohamed Hilmy,Ghozlan, Said Ahmed Soliman,Abdelrazek, Fathy Mohamed,Selim, Maghraby Ali
, p. 1021 - 1032 (2007/10/02)
The thiopyran derivative 3 was obtained from the reaction of cyanothioacetamide 2 with formaldehyde and malononitrile.Compound 3 is converted into the pyridinethione 5 on long reflux in ethanolic triethylamine solution.The pyridinethione 7 is produced from reaction of 2 with acetaldehyde and malononitrile.Compound 7 afforded 9 on reaction with 1a, R = Ph, and 11 on treatment with phenacyl bromide.The pyran derivative 13, formed in analogous manner from 12, afforded 19 on further reaction with formaldehyde and malononitrile, and 22 on reaction with acetic anhydride.Whereas the pyranopyrazole 27 is formed from 25a on reaction with formaldehyde and malononitrile in refluxing ethanol, 25b afforded only 28 an similar treatment.Similarly, thiazolopyridine derivative 30 and phthalazine 32 were formed from 29 and 31 respectively.
