134843-13-3Relevant academic research and scientific papers
4-Amino-5-vinyl-3(2H)-pyridazinones and analogues as potent antinociceptive agents: Synthesis, SARs, and preliminary studies on the mechanism of action
Vergelli, Claudia,Giovannoni, Maria Paola,Pieretti, Stefano,Giannuario, Amalia Di,Piaz, Vittorio Dal,Biagini, Pierfrancesco,Biancalani, Claudio,Graziano, Alessia,Cesari, Nicoletta
, p. 5563 - 5575 (2008/03/14)
A series of 4-amino-5-vinyl-3(2H)-pyridazinones and analogues were synthesized and their antinociceptive effect was evaluated in the mouse abdominal constriction model. Several of the novel compounds showed ED50 values in the range 6-20 mg/kg/s
5-Acyl-6-aryl-4-nitro-3(2H)pyridazinones and related 4-amino compounds: Synthesis and pharmacological evaluation
Dal Piaz,Ciciani,Turco,Giovannoni,Miceli,Pirisino,Perretti
, p. 341 - 348 (2007/10/02)
Several 4-nitro- and 4-amino-5-acyl-6-aryl-3(2H)pyridazinones were prepared and their in vitro and ex vivo antiaggregatory properties were evaluated. 4-Nitro derivatives 3 generally showed good activity in vitro towards arachidonic acid (AA)-induced human
