134852-87-2Relevant articles and documents
AN ENANTIOSELECTIVE TOTAL SYNTHESIS OF THE MACRODIOLIDE (-)-(RRR)-COLLETALLOL
Dommerholt, F. J.,Thijs, L.,Zwanenburg, B.
, p. 1495 - 1498 (1991)
The total synthesis of (-)-colletallol, a naturally occurring macrodiolide, has been completed in 26 steps.An essential step in the sequence is the photo-induced rearrangement of an α,β-epoxy diazomethyl ketone to produce a 4-hydroxy-2-alkenoate.
Total synthesis of the macrodiolide pyrenophorol
Dommerholt,Thijs,Zwanenburg
, p. 1499 - 1502 (2007/10/02)
By means of a total synthesis, the absolute configuration of the naturally occurring macrodiolide pyrenophorol has been established. An essential step is the photo-induced rearrangement of an α,β-epoxy diazomethyl ketone to produce a 4-hydroxy-2-alkenoate. The two lactone units have been introduced in two successive steps.