134855-95-1

Usage

Uses

Used in Pharmaceutical Research and Drug Development:
Phenol, 4-(1-aminoethyl)-2-methoxy-, (R)(9CI) is used as a research compound for its structural similarity to R-(-)-Rolipram, which is a selective inhibitor of the enzymatic breakdown of cyclic AMP. This makes it a valuable tool in studying the effects of cyclic AMP on various central nervous system disorders and potentially developing new treatments for these conditions.
Used in the Treatment of Central Nervous System Disorders:
Phenol, 4-(1-aminoethyl)-2-methoxy-, (R)(9CI) may be used as a therapeutic agent in the treatment of various central nervous system disorders due to its potential to inhibit the enzymatic breakdown of cyclic AMP. Phenol, 4-(1-aminoethyl)-2-methoxy-, (R)(9CI)'s ability to modulate cyclic AMP levels could have implications for conditions such as asthma, chronic obstructive pulmonary disease (COPD), and other inflammatory disorders.
Used in Drug Delivery Systems:
In the future, Phenol, 4-(1-aminoethyl)-2-methoxy-, (R)(9CI) may be incorporated into drug delivery systems to improve its bioavailability, targeting, and therapeutic outcomes. The development of novel drug delivery systems, such as nanoparticles or other carriers, could enhance the compound's efficacy and minimize potential side effects.
Note: The specific applications and industries for Phenol, 4-(1-aminoethyl)-2-methoxy-, (R)(9CI) are not explicitly mentioned in the provided materials. The uses listed above are inferred based on the compound's structural similarity to R-(-)-Rolipram and its potential role in pharmaceutical research and drug development. Further research and development are necessary to fully understand and validate its applications in various industries.

Upstream product

• 498-02-2 1-(3-methoxy-4-hydroxyphenyl)ethanone 
• 38489-85-9 3'-methoxy-4'-hydroxyacetophenone oxime 

Downstream Products

• 1391847-96-3 C₁₈H₂₉NO₃ 
• 1391847-98-5 C₂₁H₂₈N₂O₂S 
• 1391847-99-6 C₁₆H₂₆N₂O₄ 
• 1391848-00-2 C₂₃H₃₃N₃O₂S 
• 1391848-03-5 C₂₈H₄₁N₃O₄S 
• 1391847-95-2 C₂₇H₄₅NO₃ 
• 1391847-97-4 C₁₉H₃₁NO₃ 
• 2880-58-2 2-methoxy-1,4-benzoquinone 

Relevant academic research and scientific papers

Method for preparing primary amine by catalyzing reductive amination of aldehyde ketone compounds

The invention discloses a method for preparing primary amine by catalyzing reductive amination of aldehyde ketone compounds. The method comprises the following steps: 1) mixing nickel nitrate hexahydrate, citric acid and an organic solvent, carrying out heating and stirring until a colloidal material is obtained, drying the colloidal material, roasting the colloidal material in a protective atmosphere, pickling, washing and drying a roasted product, and performing a partial oxidation reaction on a dried product in an oxygen-nitrogen mixed atmosphere to obtain a catalyst for a reductive amination reaction; and 2) mixing aldehyde or ketone compounds, a methanol solution of ammonia and the reductive amination reaction catalyst, introducing hydrogen, and carrying out a reductive amination reaction. The method has the advantages of high primary amine yield, high selectivity, wide aldehyde ketone substrate range, short reaction time, mild reaction conditions, low cost, greenness, economicalperformance and the like; the used reductive amination reaction catalyst can be recycled more than 10 times, and the catalytic activity of the catalyst is not obviously changed in gram-level reactions; and the method is suitable for large-scale application.

SYNTHESIS OF AMIDES AND AMINES FROM ALDEHYDES OR KETONES BY HETEROGENEOUS METAL CATALYSIS

This invention concerns the first mild and efficient synthesis of primary amines and amides from aldehydes or ketones using a heterogeneous metal catalystand amine donor. The initial heterogeneous metal- catalyzed reaction between the carbonyl and the amine donor components is followed up with the addition of a suitable acylating agent component in one-pot. Hence, the present invention provides a novel catalytic one-pot three-component synthesis of amides. Moreover, the integration of enzyme catalysis allows for eco-friendly one-pot co-catalytic synthesis ofamides from aldehyde and ketone substrates, respectively. The process can be applied to the co-catalytic one-pot three-component synthesis of capsaicin and its analogues from vanillin or vanillyl alcohol. It can also be applied for asymmetric synthesis. In the present invention, a novel co-catalytic reductive amination/dynamic kinetic resolution (dkr) relay sequence for the asymmetric synthesis of optically active amides from ketones is disclosed. Moreover, implementation of a catalytic reductive amination/kinetic resolution (kr) relay sequence produces the corresponding optically active amide product and optical active primary amine product with the opposite stereochemistry from the starting ketones.

Integrated Heterogeneous Metal/Enzymatic Multiple Relay Catalysis for Eco-Friendly and Asymmetric Synthesis

Organic synthesis is in general performed using stepwise transformations where isolation and purification of key intermediates is often required prior to further reactions. Herein we disclose the concept of integrated heterogeneous metal/enzymatic multiple relay catalysis for eco-friendly and asymmetric synthesis of valuable molecules (e.g., amines and amides) in one-pot using a combination of heterogeneous metal and enzyme catalysts. Here reagents, catalysts, and different conditions can be introduced throughout the one-pot procedure involving multistep catalytic tandem operations. Several novel cocatalytic relay sequences (reductive amination/amidation, aerobic oxidation/reductive amination/amidation, reductive amination/kinetic resolution and reductive amination/dynamic kinetic resolution) were developed. They were next applied to the direct synthesis of various biologically and optically active amines or amides in one-pot from simple aldehydes, ketones, or alcohols, respectively.

The SAR analysis of TRPV1 agonists with the α-methylated B-region

A series of TRPV1 agonists with amide, reverse amide, and thiourea groups in the B-region and their corresponding α-methylated analogues were investigated. Whereas the α-methylation of the amide B-region enhanced the binding affinities and potencies as agonists, that of the reverse amide and thiourea led to a reduction in receptor affinity. The analysis indicated that proper hydrogen bonding as well as steric effects in the B-region are critical for receptor binding.