134855-95-1

Basic information

• Product Name: Phenol, 4-(1-aminoethyl)-2-methoxy-, (R)- (9CI)
• Synonyms: Phenol, 4-(1-aminoethyl)-2-methoxy-, (R)- (9CI);Phenol, 4-(1-aminoethyl)-2-methoxy-, (R)-;4-[(1R)-1-aMinoethyl]-2-Methoxy-;4-((1R)-1-AMINOETHYL)-2-METHOXYPHENOL;Phenol,4-[(1R)-1-aminoethyl]-2-methoxy-
• CAS NO: 134855-95-1
• Molecular Formula: C₉H₁₃NO₂
• Molecular Weight: 167.21
• Mol File: 134855-95-1.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Phenol, 4-(1-aminoethyl)-2-methoxy-, (R)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 4-(1-aminoethyl)-2-methoxy-, (R)- (9CI)(134855-95-1)
• EPA Substance Registry System: Phenol, 4-(1-aminoethyl)-2-methoxy-, (R)- (9CI)(134855-95-1)

Safety Data

• Hazardous Substances Data: 134855-95-1(Hazardous Substances Data)

Usage

General Description

Phenol, 4-(1-aminoethyl)-2-methoxy-, (R)- (9CI) is a chemical compound with the molecular formula C9H13NO2. It is a stereoisomer of the chemical compound commonly known as R-(-)-Rolipram, which is a selective inhibitor of the enzymatic breakdown of cyclic AMP. The compound has a phenolic structure with a methoxy and an aminoethyl group attached to it. It may have potential applications in pharmaceutical research and drug development due to its structural similarity to R-(-)-Rolipram, which has been implicated in the treatment of various central nervous system disorders. Additional research is needed to fully understand the potential uses and effects of this chemical compound.

Upstream product

• 498-02-2 1-(3-methoxy-4-hydroxyphenyl)ethanone 
• 38489-85-9 3'-methoxy-4'-hydroxyacetophenone oxime 

Downstream Products

• 1391847-96-3 C₁₈H₂₉NO₃ 
• 1391847-98-5 C₂₁H₂₈N₂O₂S 
• 1391847-99-6 C₁₆H₂₆N₂O₄ 
• 1391848-00-2 C₂₃H₃₃N₃O₂S 
• 1391848-03-5 C₂₈H₄₁N₃O₄S 
• 1391847-95-2 C₂₇H₄₅NO₃ 
• 1391847-97-4 C₁₉H₃₁NO₃ 
• 2880-58-2 2-methoxy-1,4-benzoquinone 

Relevant articles and documents

Method for preparing primary amine by catalyzing reductive amination of aldehyde ketone compounds

The invention discloses a method for preparing primary amine by catalyzing reductive amination of aldehyde ketone compounds. The method comprises the following steps: 1) mixing nickel nitrate hexahydrate, citric acid and an organic solvent, carrying out heating and stirring until a colloidal material is obtained, drying the colloidal material, roasting the colloidal material in a protective atmosphere, pickling, washing and drying a roasted product, and performing a partial oxidation reaction on a dried product in an oxygen-nitrogen mixed atmosphere to obtain a catalyst for a reductive amination reaction; and 2) mixing aldehyde or ketone compounds, a methanol solution of ammonia and the reductive amination reaction catalyst, introducing hydrogen, and carrying out a reductive amination reaction. The method has the advantages of high primary amine yield, high selectivity, wide aldehyde ketone substrate range, short reaction time, mild reaction conditions, low cost, greenness, economicalperformance and the like; the used reductive amination reaction catalyst can be recycled more than 10 times, and the catalytic activity of the catalyst is not obviously changed in gram-level reactions; and the method is suitable for large-scale application.

Integrated Heterogeneous Metal/Enzymatic Multiple Relay Catalysis for Eco-Friendly and Asymmetric Synthesis

Organic synthesis is in general performed using stepwise transformations where isolation and purification of key intermediates is often required prior to further reactions. Herein we disclose the concept of integrated heterogeneous metal/enzymatic multiple relay catalysis for eco-friendly and asymmetric synthesis of valuable molecules (e.g., amines and amides) in one-pot using a combination of heterogeneous metal and enzyme catalysts. Here reagents, catalysts, and different conditions can be introduced throughout the one-pot procedure involving multistep catalytic tandem operations. Several novel cocatalytic relay sequences (reductive amination/amidation, aerobic oxidation/reductive amination/amidation, reductive amination/kinetic resolution and reductive amination/dynamic kinetic resolution) were developed. They were next applied to the direct synthesis of various biologically and optically active amines or amides in one-pot from simple aldehydes, ketones, or alcohols, respectively.