134856-47-6Relevant articles and documents
Construction of All-Carbon Quaternary Stereocenters by Scandium-Catalyzed Intramolecular C-H Alkylation of Imidazoles with 1,1-Disubstituted Alkenes
Lou, Shao-Jie,Mo, Zhenbo,Nishiura, Masayoshi,Hou, Zhaomin
, p. 1200 - 1205 (2020/02/04)
The exo-selective C-H cycloaddition of imidazoles to 1,1-disubstituted alkenes has been achieved for the first time by using half-sandwich scandium catalysts. A wide range of imidazole compounds bearing various 1,1-disubstituted aliphatic alkenes, styrenes, dienes, and enynes have been selectively converted in high yields to the corresponding bicyclic imidazole derivatives bearing β-all-carbon-substituted quaternary stereocenters. By using a chiral half-sandwich scandium catalyst, the asymmetric exo-selective cyclization has also been achieved with a high level of enantioselectivity.
A metal catalysed route to benzimidazoles containing a fused alicyclic ring
Anastasiou,Chaouk,Jackson
, p. 2499 - 2500 (2007/10/02)
Rhodium catalysed reactions of N-alkenyl-1,2-diaminobenzenes (1) with hydrogen and carbon monoxide give benzimidazoles containing a fused alicyclic ring (6,7) in excellent yields.