134895-48-0

Upstream product

• 139630-83-4 3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-3-(5-butyl-thiophen-2-yl)-2-methyl-propyl ester 
• 10522-26-6 2-methyl-1-undecanol 
• 20445-33-4 (R)-methoxytrifluoromethylphenylacetyl chloride 

Relevant academic research and scientific papers

Enantioselective Synthesis of (S)-2-Methyl-1-alkanols via Bakers'Yeast Mediated Reduction of α-Methyl-2-thiophenepropenals

The bakers'yeast mediated enantioselective reductions of some α-methyl-5-(1-alkyl)-2-thiophenepropenals 3 are described.These furnished (S)-β-methyl-5-(1-alkyl)-2-thiophenepropanols 5 in good to high enantiomeric excesses (76-98percent ee).An alternative approach to (S)-β-methyl-5-(1-alkyl)-2-thiophenepropanols 5d-f (98percent ee) is also described.Raney nickel reduction of their acetates, followed by hydrolysis, provided (S)-2-methyl-1-alkanols 2b-f of unchanged optical purities.

Kinetic Resolution of Racemic Aldehydes by Enantioselective Alkylation

Various types of racemic aldehydes were kinetically resolved with diethylzinc in the presence of a catalytic amount of a chiral β-amino alcohol.Kinetic resolution of racemic chloro(phenyl)acetaldehyde gave an optically active form as an unchanged substrate, which could be converted into styrene oxide in high optical purity (97.5percent ee).