13491-41-3

Upstream product

• 87418-88-0 1-[(2R,3S,4R,5R)-3,4-Bis-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione 
• 3083-77-0 araU 
• 82855-62-7 4-(1,2,4-triazol-1-yl)-1-(2',3',5'-tri-O-acetyl-β-D-arabinofuranosyl)pyrimidine-2(1H)one 

Relevant academic research and scientific papers

N4-HYDROXYCYTIDINE AND DERIVATIVES AND ANTI-VIRAL USES RELATED THERETO

This disclosure relates to certain N4-hydroxycytidine derivatives, compositions, and methods related thereto. In certain embodiments, the disclosure relates to the treatment or prophylaxis of a Zika virus infection.

N4-HYDROXYCYTIDINE AND DERIVATIVES AND ANTI-VIRAL USES RELATED THERETO

This disclosure relates to N4-hydroxycytidine derivatives, compositions, and methods related thereto. In certain embodiments, the disclosure relates to the treatment and prophylaxis of viral infections.

Anti-HCV nucleoside derivatives

The present invention comprises novel and known purine and pyrimidine nucleoside derivatives which have been discovered to be active against hepatitis C virus (HCV). The use of these derivatives for the treatment of HCV infection is claimed as are the novel nucleoside derivatives disclosed herein.

Synthesis of 4-Alkylcytosine Nucleosides and Evaluation of Cytostatic Activity in the L1210 Murine Leukemia

4-Alkylcytosine nucleosides 2 were prepared by nucleophilic substitution of the 4-(1,2,4-triazol-1-yl) residue of uracil nucleoside derivatives 1 using different amino compounds.The antitumor activity against L1210 murine leukemia of fifteen 4-alkylcytosine nucleosides dissolved in buffer or incorporated into liposomes was tested.Liposomal 1-(β-D-arabinofuranosyl)-4-octadecylamino-2(1H)-pyrimidinone (2d) having the highest activity gave an increase of life span (ILS) of 706percent and 6/6 survivors at 400 μmol/kg.The structurally related and well-known antitumor drug 1-(β-D-arabinofuranosyl)cytosine (araC) dissolved in buffer gave only 179percent ILS and 0/6 survivors under corresponding conditions.Derivatives 2a-c and 2e-f having shorter or longer alkyl chains were less active.All the other derivatives showed no antitumor effect.The activity of the 4-alkylcytosine nucleoside was also lost, when the arabinose residue was replaced by ribose or deoxyribose. - Key Words: Nucleosides / Murine leukemia / Liposomes / Leukemia / Cytosine / Antitumor agents / Carbohydrates

Pyrimidine nucleosides. 6. Syntheses and anticancer activities of N4 substituted 2,2' anhydronucleosides

Some derivatives of N4 substituted 2,2' cyclo araC [N4 hydroxy, N4 methoxy, N4 methyl, and N4phenyl] which are potential carcinostatic nucleosides were prepared by introducing the 2,2' anhydro linkage