1349172-89-9Relevant academic research and scientific papers
Studies on the anticonvulsant activity and influence on GABA-ergic neurotransmission of 1,2,4-triazole-3-thione-based compounds
Plech, Tomasz,Kapron, Barbara,Luszczki, Jarogniew J.,Wujec, Monika,Paneth, Agata,Siwek, Agata,Kolaczkowski, Marcin,Zolnierek, Maria,Nowak, Gabriel
, p. 11279 - 11299 (2014/09/29)
The anticonvulsant activity of several 1,2,4-triazole-3-thione derivatives on mouse maximal electroshock-induced seizures was tested in this study. Characteristic features of all active compounds were rapid onset of action and long lasting effect. Structure-activity observations showed that the probability of obtaining compounds exerting anticonvulsant activity was much higher when at least one of the phenyl rings attached to 1,2,4-triazole nucleus had a substituent at the para position. The obtained results, moreover, permit us to conclude that despite the structural similarity of loreclezole (second-generation anticonvulsant drug) and the titled compounds, their anticonvulsant activity is achieved via completely different molecular mechanisms.
Synthesis and antibacterial activity of some novel N2-hydroxymethyl and N2-aminomethyl derivatives of 4-aryl-5-(3-chlorophenyl)-2,4-dihydro-3H-1,2,4- triazole-3-thione
Plech, Tomasz,Wujec, Monika,Kapron, Barbara,Kosikowska, Urszula,Malm, Anna
experimental part, p. 737 - 743 (2012/01/05)
In this investigation, several novel N2-hydroxymethyl and N2-aminomethyl derivatives of 5-(3-chlorophenyl)-4-(4-methylphenyl)-2,4-dihydro- 3H-1,2,4-triazole-3-thione and 4-(4-bromophenyl)- 5-(3-chlorophenyl)-2,4- dihydro-3H-1,2,4-triazole-3- thione were prepared. All synthesized compounds were screened for their antibacterial activity against six Gram-positive and four Gram-negative bacterial strains.
