134935-85-6Relevant academic research and scientific papers
Synthesis of 3,4-disubsituted isoxazoles via enamine [3+2] cycloaddition
Jia, Qian-Fa,Benjamin, Pooiming Shurn,Huang, Jiayao,Du, Zhiyun,Zheng, Xi,Zhang, Kun,Conney, Allan H.,Wang, Jian
, p. 79 - 84 (2013/02/23)
Enamine-triggered [3+2]-cycloaddition reactions of aldehydes and N-hydroximidoyl chlorides in the presence of triethylamine give rise to 3,4-disubstituted isoxazoles upon oxidation of the cycloadduct 3,4,5-trisubstituted 5-(pyrrolidinyl)-4,5-dihydroisoxazoles. This offers a high yielding, regiospecific and metal-free synthetic route for the synthesis of 3,4-disubstituted isoxazoles. Georg Thieme Verlag Stuttgart · New York.
