134949-02-3Relevant articles and documents
Hydrophilic Pd-phosphines catalyzed one-pot synthesis of substituted isoquinolines, furopyridines and thienopyridines in aqueous medium
Guguloth, Veeranna,Thirukovela, Narasimha Swamy,Balaboina, Ramesh,Paidakula, Suresh,Vadde, Ravinder
supporting information, p. 297 - 299 (2019/01/04)
A first example of simple and efficient hydrophilic Pd-phosphine complexes catalyzed one-pot three-component reaction of ortho-bromo aldehydes, terminal alkynes and ammonium acetate proceeds through the tandem coupling-imination-annulation path for the synthesis of substituted isoquinolines, furopyridines and thienopyridines in good to excellent yields in green aqueous medium at mild temperature was described.
One substrate, two modes of C-H functionalization: A metal-controlled site-selectivity switch in C-H arylation reactions
Tiwari, Virendra Kumar,Kamal, Neha,Kapur, Manmohan
supporting information, p. 262 - 265 (2017/11/27)
A unique site-selectivity switch has been achieved in the ruthenium-catalyzed C-H arylation reaction of N-acetyl-1,2-dihydroisoquinolines. This metal-mediated switch is antipodal to the previous report on the palladium-mediated C-4 C-H arylation on the same substrate. Mechanistic details reveal interesting aspects of the reaction pathway, and kinetic studies bring out the difference in the modes of C-H activation adopted by the two catalytic systems.
Palladium meets copper: One-pot tandem synthesis of pyrido fused heterocycles: Via Sonogashira conjoined electrophilic cyclization
Kumar, Sonu,Saunthwal, Rakesh K.,Aggarwal, Trapti,Kotla, Siva K. Reddy,Verma, Akhilesh K.
supporting information, p. 9063 - 9071 (2016/10/09)
An efficient step-economical tandem approach for the direct synthesis of pyrido fused indole, quinoline, benzofuran and benzothiophene derivatives using a bimetallic Pd/Cu catalytic system has been described. The three component reaction of o-halo aldehyd
Synthesis of substituted isoquinolines via iminoalkyne cyclization using Ag(i) exchanged K10-montmorillonite clay as a reusable catalyst
Jeganathan, Mariappan,Pitchumani, Kasi
, p. 38491 - 38497 (2014/11/08)
Monosubstituted isoquinolines are synthesized in good to excellent yields by the Ag(i)-exchanged K10-montmorillonite clay catalyzed ring closure of iminoalkynes. This silver catalyzed ring closure is highly effective in cyclizing aryl- and alkyl-substituted iminoalkynes at 100 °C and accommodates a variety of iminoalkynes, thus affording a convenient route to the synthesis of isoquinolines. The other salient features of this procedure are its reusability, environmentally benign nature, high yield, operational simplicity with fewer steps, easy separation, and minimization of metallic wastes. The reaction proceeds smoothly in moderate yields and tolerates various functional groups. The solid catalyst can be readily recovered and reused. Notably, no additional base or other co-catalysts are needed. A plausible mechanism is proposed in which isoquinolines are formed via simultaneous bifunctional acid-base catalysis by Ag(i) clay. the Partner Organisations 2014.
Synthesis of substituted isoquinolines via iminoalkyne cyclization using Ag(i) exchanged K10-montmorillonite clay as a reusable catalyst
Jeganathan, Mariappan,Pitchumani, Kasi
, p. 38491 - 38497 (2014/12/11)
Monosubstituted isoquinolines are synthesized in good to excellent yields by the Ag(i)-exchanged K10-montmorillonite clay catalyzed ring closure of iminoalkynes. This silver catalyzed ring closure is highly effective in cyclizing aryl- and alkyl-substituted iminoalkynes at 100 °C and accommodates a variety of iminoalkynes, thus affording a convenient route to the synthesis of isoquinolines. The other salient features of this procedure are its reusability, environmentally benign nature, high yield, operational simplicity with fewer steps, easy separation, and minimization of metallic wastes. The reaction proceeds smoothly in moderate yields and tolerates various functional groups. The solid catalyst can be readily recovered and reused. Notably, no additional base or other co-catalysts are needed. A plausible mechanism is proposed in which isoquinolines are formed via simultaneous bifunctional acid-base catalysis by Ag(i) clay. This journal is
Facile synthesis of 3-substituted isoquinolines derivatives via microwave-assisted tandem three-component coupling cyclization
Lin, Long,Wu, Qiongyou,Huang, Shaowei,Yang, Guangfu
experimental part, p. 1075 - 1082 (2012/08/07)
A novel three-component reaction of o-bromobenzaldehyde, terminal alkynes and tert-butyl amine has been established, which proceeded smoothly to give 3-substituted isoquinolines in good yields in the presence of palladium/copper catalysts under microwave irradiation.
1H and 13C NMR Spectra of Fifteen Substituted Isoquinolines
Nelson, Janis T.,Davis, Roman
, p. 513 - 517 (2007/10/02)
Detailed analyses of the 1H and 13C NMR spectra of fifteen momo- and di-substituted isoquinoline derivatives were carried out by two-dimensional 1H-1H and 1H-13C shift correlation and nuclear Overhauser effect difference techniques.
