1349752-80-2Relevant academic research and scientific papers
Discovery of potent, selective, and orally bioavailable PDE5 inhibitor: Methyl-4-(3-chloro-4-methoxybenzylamino)-8-(2-hydroxyethyl)-7-methoxyqui nazolin-6-ylmethylcarbamate (CKD 533)
Choi, Hojin,Lee, Jaekwang,Kim, Young Hoon,Im, Dai Sig,Hwang, In-Chang,Kim, Soo Jin,Moon, Seung Kee,Lee, Hong Woo,Lee, Sung Sook,Ahn, Soon Kil,Kim, Sang Woong,Choi, Nam Song,Lee, Kyung Joo
, p. 383 - 386 (2010)
In a continuing effort to discover novel PDE5 inhibitors, we have successfully found quinazolines with 4-benzylamino substitution as potent and selective PDE5 inhibitors. Initial lead compound (1) was found to be easily metabolized when incubated with hum
