134983-83-8

Upstream product

• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 4934-95-6 methyl 2-(2-oxocyclopentyl)acetate 
• 120-92-3 cyclopentanone 

Downstream Products

• 134983-85-0 {1-(2-Benzenesulfonyl-ethyl)-2-[(E)-(R)-1-phenyl-ethylimino]-cyclopentyl}-acetic acid methyl ester 
• 183477-42-1 (1S,5S)-2-((R)-1-phenylethyl)-2-azabicyclo[3.3.0]octan-3-one 
• 131348-76-0 (1S,5S)-2-azabicyclo<3.3.0>octan-3-one 

Relevant academic research and scientific papers

Asymmetric intramolecular crossed-benzoin reactions by N-heterocyclic carbene catalysis

(Chemical Equation Presented) Getting cross: Excellent asymmetric inductions and very good yields are achieved in the generation of a quaternary stereocenter in α-hydroxy-substituted tetralones by using chiral N-heterocyclic carbene catalysts in an enantioselective intramolecular crossed-benzoin reaction. The synthesis of the corresponding α-hydroxyindanones with good ee values is also possible by this route.

ASYMMETRIC MICHAEL ADDITION OF CHIRAL IMINES TO PHENYLVINYLSULFONE: PREPARATION OF KEY CHIRAL BUILDING BLOCKS FOR THE SYNTHESIS OF ASPIDOSPERMA AND HUNTERIA ALKALOIDS

Addition of chiral imine 8 to phenylvinylsulfone 9 led, after hydrolytic work-up to adduct 11 (91percent stereoselectivity).This derivative has been converted into target cyclopentanones 14 and 16.