1349901-44-5

Upstream product

• 1224161-49-2 (3aR,7S,7aS)-ethyl-7-acetamido-2,2-dimethyl-6-oxo-3a,6,7,7a-tetrahydrobenzo[d]-[1,3]dioxole-4-carboxylate 
• 1173701-23-9 (1R,2S,6S,7S)-9-acetyl-4,4-dimethyl-3,5,8-trioxa-9-aza-tricyclo[5.2.2.0.2.6]undec-10-ene-7-carboxylic acid ethyl ester 
• 1185040-54-3 (+)-ethyl (3aR,7aS)-2,2-dimethyl-3a,7a-dihydrobenzo[d][1,3]dioxole-4-carboxylate 
• 1173701-22-8 (+)-ethyl (5S,6R)-5,6-dihydroxycyclohexa-1,3-dienecarboxylate 
• 1173701-24-0 ethyl (3aS,4S,7R,7aS)-7-(acetylamino)-4-hydroxy-2,2-dimethyl-3a,4,7,7a-tetrahydro-1,3-benzodioxole-4-carboxylate 
• 1224161-50-5 (3aR,7R,7aS)-ethyl-7-acetamido-6-(hydroxyimino)-2,2-dimethyl-3a,6,7,7a-tetrahydrobenzo[d][1,3]dioxole-4-carboxylate 

Relevant academic research and scientific papers

Several generations of chemoenzymatic synthesis of oseltamivir (Tamiflu): Evolution of strategy, quest for a process-quality synthesis, and evaluation of efficiency metrics

Four generations of chemoenzymatic approaches to oseltamivir are presented. The first two generations relied on the use of cyclohexadiene-cis-diol derived enzymatically from bromobenzene. The third and fourth generation used the corresponding diol obtaine

Short chemoenzymatic azide-free synthesis of oseltamivir (tamiflu): Approaching the potential for process efficiency

A short chemoenzymatic and azide-free synthesis of oseltamivir was attained with the key steps consisting of a one-pot Dauben-Michno oxidative transposition and animation and a reductive transposition of an acrylate.