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1349904-82-0

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1349904-82-0 Usage

General Description

Taccalonolide AJ is a natural product isolated from plants of the Tacca genus and has demonstrated potent anticancer activity in pre-clinical studies. It functions by disrupting microtubule dynamics, leading to mitotic arrest and subsequent cell death. Taccalonolide AJ has shown efficacy against a broad range of cancer cell types, including those resistant to traditional chemotherapeutic agents. Its unique mechanism of action and ability to overcome drug resistance make it a promising candidate for the development of novel cancer therapies. Further research is needed to fully understand the potential clinical applications of taccalonolide AJ and its safety profile.

Check Digit Verification of cas no

The CAS Registry Mumber 1349904-82-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,4,9,9,0 and 4 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1349904-82:
(9*1)+(8*3)+(7*4)+(6*9)+(5*9)+(4*0)+(3*4)+(2*8)+(1*2)=190
190 % 10 = 0
So 1349904-82-0 is a valid CAS Registry Number.

1349904-82-0Upstream product

1349904-82-0Downstream Products

1349904-82-0Relevant articles and documents

Potent taccalonolides, AF and AJ, inform significant structure-activity relationships and tubulin as the binding site of these microtubule stabilizers

Li, Jing,Risinger, April L.,Peng, Jiangnan,Chen, Zhongliang,Hu, Lihong,Mooberry, Susan L.

, p. 19064 - 19067 (2011)

The taccalonolides are a class of microtubule stabilizing agents isolated from plants of the genus Tacca. In efforts to define their structure-activity relationships, we isolated five new taccalonolides, AC-AF and H2, from one fraction of an ethanol extract of Tacca plantaginea. The structures were elucidated using a combination of spectroscopic methods, including 1D and 2D NMR and HR-ESI-MS. Taccalonolide AJ, an epoxidation product of taccalonolide B, was generated by semisynthesis. Five of these taccalonolides demonstrated cellular microtubule-stabilizing activities and antiproliferative actions against cancer cells, with taccalonolide AJ exhibiting the highest potency with an IC 50 value of 4.2 nM. The range of potencies of these compounds, from 4.2 nM to >50 μM, for the first time provides the opportunity to identify specific structural moieties crucial for potent biological activities as well as those that impede optimal cellular effects. In mechanistic assays, taccalonolides AF and AJ stimulated the polymerization of purified tubulin, an activity that had not previously been observed for taccalonolides A and B, providing the first evidence that this class of microtubule stabilizers can interact directly with tubulin/microtubules. Taccalonolides AF and AJ were able to enhance tubulin polymerization to the same extent as paclitaxel but exhibited a distinct kinetic profile, suggesting a distinct binding mode or the possibility of a new binding site. The potencies of taccalonolides AF and AJ and their direct interaction with tubulin, together with the previous excellent in vivo antitumor activity of this class, reveal the potential of the taccalonolides as new anticancer agents.

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