134991-79-0

Upstream product

• 675-10-5 4-hydroxy-6-methyl-2-pyron 
• 63897-12-1 2,4-dichloro-6-methyl-3-nitropyridine 
• 5188-07-8 sodium thiomethoxide 
• 134992-24-8 2,4-bis(methylthio)-6-methyl-3-nitropyridine 

Downstream Products

• 166253-17-4 phenyl N-[2,4-bis(methylthio)-6-methylpyridin-3-yl]carbamate 
• 186024-36-2 N-[2,4-bis(methylthio)-6-methyl-3-pyridyl]-α-hexylthio-3,4-dichloro-phenylacetamide 
• 167303-93-7 N-[2,4-bis(methylthio)-6-methylpyridin-3-yl]-2-hexylthiodecanoic amide 
• 561023-90-3 2-[4-[2-(benzimidazol-2-ylthio)ethyl]piperazin-1-yl]-N-[2,4-bis(methylthio)-6-methyl-3-pyridyl]acetamide 
• 176495-38-8 N-[2,4-bis(methylthio)-6-methylpyridin-3-yl]-2-phenacylthioacetamide 
• 179054-51-4 1-cycloheptyl-1-[4-(4-fluoro-phenoxy)-benzyl]-3-(6-methyl-2,4-bis-methylsulfanyl-pyridin-3-yl)-urea 

Relevant academic research and scientific papers

4-aryl-3-(heteroarylureido)quinoline derivatves

Compounds of the formula STR1 and the pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, m, X and Q are as defined below, and novel intermediates used in the synthesis of such compounds. The comp

Derivatives of cyclic ethers and sulfides for the treatment of atherosclerosis

The present invention provides compounds of Formula I, STR1 or a pharmaceutically acceptable salt forms thereof, which are inhibitors of acyl-Coenzyme A: cholesterol O-acyltransferase (ACAT), pharmaceutical compositions containing such compounds, processes for the preparation of such compounds, and the use of such compounds as antihypercholesterolemic and/or antiatherosclerotic agents.

Amides for the treatment of atherosclerosis

This invention provides amide compounds as inhibitors of acyl-Coenzyme A: cholesterol O-acyltransferase (ACAT), pharmaceutical compositions containing such compounds, processes for the preparation of such compounds, and the use of such compounds as antihypercholesterolemic and/or antiatherosclerotic agents.

Intermediates for making N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT)

Compounds of the formula STR1 wherein R21 and R22 are as defined in the specification which are intermediates useful in the preparation of compounds of the formula STR2 and the pharmaceutically acceptable salts thereof, wherein Q and R1 are as defined in the specification. The compounds of formula I are inhibitors of acyl coenzyme A: cholesterol acyltransferase (ACAT) and are useful as hypolipidemic and antiatherosclerosis agents.

New N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase

Compounds of the formula the pharmaceutically acceptable salts thereof, wherein Q and R1 are as defined below, and novel carboxylic acid and acid halide intermediates used in the synthesis of such compounds. The compounds of formula I are inhibitors of acyl coenzyme A: cholesterol acyltransferase (ACAT) and are useful as hypolipidemic and antiatherosclerosis agents.