135-87-5 Usage
Uses
Used in Pharmaceutical Industry:
1-[(2,3-dihydro-1,4-benzodioxin-2-yl)methyl]piperidinium chloride is used as a pharmaceutical agent for its potential interaction with α2-adrenergic receptors (α2-ARs). It acts as an antagonist, with Kis values of 5.4, 2, and 1.3 nM for α2A-, α2B-, and α2C-ARs, respectively. This property allows it to reverse the decreases in systolic blood pressure induced by clonidine in spontaneously hypertensive rats when administered at a dose of 10 mg/kg.
Used in Research Applications:
In addition to its potential therapeutic uses, 1-[(2,3-dihydro-1,4-benzodioxin-2-yl)methyl]piperidinium chloride can be utilized in research settings to study the effects of α2-AR antagonists on various physiological processes. Its ability to interact with different subtypes of α2-ARs makes it a valuable tool for investigating the roles of these receptors in health and disease.
Used in Drug Development:
The compound's interaction with histamine receptors and its antagonistic properties also make it a candidate for further development as a drug targeting histamine-mediated responses. This could have implications for the treatment of conditions such as allergies, asthma, and other histamine-related disorders.
Safety Profile
Poison by
intraperitoneal and intravenous routes.
Moderately toxic by ingestion and
subcutaneous routes. Experimental
reproductive effects. When heated to
decomposition it emits very toxic fumes of
NO, and HCl.
Check Digit Verification of cas no
The CAS Registry Mumber 135-87-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,3 and 5 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 135-87:
(5*1)+(4*3)+(3*5)+(2*8)+(1*7)=55
55 % 10 = 5
So 135-87-5 is a valid CAS Registry Number.
InChI:InChI=1/C14H19NO2.ClH/c1-4-8-15(9-5-1)10-12-11-16-13-6-2-3-7-14(13)17-12;/h2-3,6-7,12H,1,4-5,8-11H2;1H
