1350176-24-7

Basic information

• Product Name: 4-(5-methoxy-2-(3-phenylisoxazol-5-yl)phenoxy)butanoic acid
• Synonyms: 4-(5-methoxy-2-(3-phenylisoxazol-5-yl)phenoxy)butanoic acid
• CAS NO: 1350176-24-7
• Molecular Weight: 353.375
• Mol File: 1350176-24-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(5-methoxy-2-(3-phenylisoxazol-5-yl)phenoxy)butanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(5-methoxy-2-(3-phenylisoxazol-5-yl)phenoxy)butanoic acid(1350176-24-7)
• EPA Substance Registry System: 4-(5-methoxy-2-(3-phenylisoxazol-5-yl)phenoxy)butanoic acid(1350176-24-7)

Safety Data

• Hazardous Substances Data: 1350176-24-7(Hazardous Substances Data)

Upstream product

• 627-00-9 γ-chlorobutyric acid 
• 1186130-66-4 5-methoxy-2-(3-phenylisoxazol-5-yl)phenol 

Relevant articles and documents

Design and synthesis of 3,5-diarylisoxazole derivatives as novel class of anti-hyperglycemic and lipid lowering agents

We have designed 1,3-disubstituted-5-membered heteroaromatic ring system as a common core motif from known anti-hyperglycemic agents. Designed compounds were synthesized and screened for in vivo anti-hyperglycemic activity in sucrose loaded model (SLM), sucrose-challenged streptozotocin-induced diabetic rat model (STZ-S) as well as db/db mice model. Some of the synthesized compounds showed promising in vivo anti-hyperglycemic as well as moderate lipid lowering activity. Synthesized Compounds were screened in various in vitro models of type-2 diabeties such as DPP-4, PTP1B and PPARγ to know the mechanism of their anti-hyperglycemic action. None of the synthesized compounds showed DPP-4 inhibitory as well as PPARγ activity. These compounds have shown promising PTP-1B inhibitory activity there by revealing that compounds exhibit anti-diabetic activity by PTP1B pathway.