1350320-74-9Relevant academic research and scientific papers
Discovery of 3-hydroxy-4-cyano-isoquinolines as novel, potent, and selective inhibitors of human 11β-hydroxydehydrogenase 1 (11β-HSD1)
Wu, Shung C.,Yoon, David,Chin, Janice,Van Kirk, Katy,Seethala, Ramakrishna,Golla, Rajasree,He, Bin,Harrity, Thomas,Kunselman, Lori K.,Morgan, Nathan N.,Ponticiello, Randolph P.,Taylor, Joseph R.,Zebo, Rachel,Harper, Timothy W.,Li, Wenying,Wang, Mengmeng,Zhang, Lisa,Sleczka, Bogdan G.,Nayeem, Akbar,Sheriff, Steven,Camac, Daniel M.,Morin, Paul E.,Everlof, John G.,Li, Yi-Xin,Ferraro, Cheryl A.,Kieltyka, Kasia,Shou, Wilson,Vath, Marianne B.,Zvyaga, Tatyana A.,Gordon, David A.,Robl, Jeffrey A.
, p. 6693 - 6698 (2011/12/05)
Derived from the HTS hit 1, a series of hydroxyisoquinolines was discovered as potent and selective 11β-HSD1 inhibitors with good cross species activity. Optimization of substituents at the 1 and 4 positions of the isoquinoline group in addition to the co
