13504-77-3

Upstream product

• 21204-67-1 methyl (triphenylphosphoranylidene)acetate 

Downstream Products

• 90484-49-4 α-Brom-trans-cumarsaeure 
• 91062-95-2 4-Brom-1-phenyl-pentadien-1,3-saeure-⁽⁵⁾ 
• 26480-86-4 methyl 2-iodo-2-(triphenylphosphoranylidene)acetate 
• 221136-02-3 (Z)-2-bromo-5-{tert-butoxycarbonyl-[5-(tert-butyldiphenylsilanyloxy)pentyl]amino}pent-2-enoic acid methyl ester 
• 253676-00-5 Methyl (4S,2E)-2-bromo-4-[N-(tert-butoxycarbonyl)amino]-5-phenylpent-2-enoate 
• 253675-99-9 Methyl (4S,2Z)-2-bromo-4-[N-(tert-butoxycarbonyl)amino]-5-phenylpent-2-enoate 
• 220324-04-9 Methyl (4S,2Z)-2-bromo-5-methyl-4-[N-(2,4,6-trimethylphenylsulfonyl)amino]hex-2-enoate 
• 253675-93-3 Methyl (4S,2E)-2-bromo-5-methyl-4-[N-(2,4,6-trimethylphenylsulfonyl)amino]hex-2-enoate 
• 287481-49-6 (E)-2-bromo-5-phenylpent-2-enoic acid methyl ester 
• 405932-40-3 (E)-2-bromo-5-[N-(4-methylphenylsulfonyl)amino]pent-2-enoate 
• 405932-38-9 (Z)-2-bromo-5-[N-(4-methylphenylsulfonyl)amino]pent-2-enoate 
• 155530-52-2 5-(N-benzyl-N-benzyloxycarbonylamino)-2-bromopent-2(Z)-enoic acid methyl ester 
• 942509-57-1 N-[(1S,Z)-3-bromo-3-methoxycarbonyl-1-methylprop-2-enyl]-2,4,6-trimethyl-N-[3-phenylprop-2-ynyl]phenylsulfonamide 
• 942509-20-8 N-[(Z)-3-bromo-3-methoxycarbonylprop-2-enyl]-2,4,6-trimethyl-N-[(E)-3-phenylprop-2-enyl]phenylsulfonamide 

Relevant academic research and scientific papers

Study toward an asymmetric and catalytic synthesis of koumine

A synthetic study of koumine, a natural product with a densely functionalized and inspiring heterocyclic skeleton, was conducted by exploring a strategy of desymmetrization of 1,3-cyclohexanedione by an intramolecular vinylation reaction of an enolate und

Flexible Total Synthesis of (±)-Aureothin, a Potent Antiproliferative Agent

Amenable to late-stage preparation of analogues, a flexible and convergent total synthesis of (±)-aureothin is presented. The strategy was based on a desymmetrization of α,α′-dimethoxy-γ-pyrone by a process combining 1,4-addition and alkylation of vinylogous enolate to stereoselectively reach the backbone of the target. Palladium-catalyzed cyanation of an elaborated and isomerizable E,Z dienyl motif followed by Pinner cyclization enabled the construction of the tetrahydrofuran motif while a first approach based on a late-stage oxidation was unsuccessful.

Biocatalyzed enantioselective reduction of activated C=C bonds: Synthesis of enantiomerically enriched α-halo-β-arylpropionic acids

The enantioselective biocatalyzed reduction of the C=C bond of some (Z)-methyl α-halo-β-arylacrylates was investigated. The reaction was performed by baker's yeast fermentation and Old Yellow Enzymes 1-3 mediated biotransformations. The final products wer

A simple synthesis of functionalized 3-bromocoumarins by a one-pot three-component reaction

Functionalized 3-bromocoumarins 2 have been, prepared, by a simple one-pot bromination/Wittig/cyclization tandem process from methyl (triphenylphosphoranylidene)acetate, Nbromosuccinimide and a series of 2-hydroxybenzaldehydes. Owing to the commercial availability of salicylaldehyde derivatives, this approach offers such a diverse range of compounds that it fulfills the recent demand for the generation of large combinatorial chemical libraries based on the coumarin scaffold