1350433-01-0Relevant academic research and scientific papers
Radiosynthesis and characterization of astemizole derivatives as lead compounds toward PET imaging of τ-pathology
Riss, Patrick J.,Brichard, Laurent,Ferrari, Valentina,Williamson, David J.,Fryer, Tim D.,Hong, Young T.,Baron, Jean-Claude,Aigbirhio, Franklin I.
, p. 852 - 855 (2013/08/26)
Formation of neurofibrillary tangles, comprising of microtubule-associated tau protein, is a hallmark of a group of neurodegenerative diseases, including Alzheimer's disease. In consequence, in vivo imaging of neurofibrillary tangles is a current focus of positron emission tomography research. Herein, development of an in vitro radioligand binding assay which uses synthetic aggregates as a model of neurofibrillary tangles is reported, together with evaluation of novel derivatives of the tau protein ligand astemizole. The Royal Society of Chemistry 2013.
Direct, nucleophilic radiosynthesis of [18F]trifluoroalkyl tosylates: Improved labelling procedures
Riss, Patrick J.,Ferrari, Valentina,Brichard, Laurent,Burke, Paul,Smith, Robert,Aigbirhio, Franklin I.
, p. 6980 - 6986,7 (2012/12/12)
A rapid and efficient protocol to afford the title compound 2-[ 18F]-fluoro-2,2-difluoroethyl tosylate ([18F]7b) is described. Starting from [18F]fluoride ion, labelling reagent 7b was obtained in good yields and a high specific radioactivity. Compound ([ 18F]7b) was then used to synthesise a prospective radiotracer for PET-imaging in dementia.
