1350442-39-5

Upstream product

• 1008-89-5 2-phenylpyridine 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 1571060-33-7 2-(2-acetoxy-5-tosylphenyl)pyridine 
• 1571059-98-7 2-(2-bromo-5-tosylphenyl)pyridine 
• 1571059-99-8 2-(2-chloro-5-tosylphenyl)pyridine 
• 1571060-01-9 2-(2-hydroxy-5-tosylphenyl)pyridine 
• 1571060-05-3 2,2'(4,4'-ditosyl[1,1'-biphenyl]2,2'-diyl)dipyridine 
• 1571060-24-6 (2-(4-(4-methylthio)phenyl)-5-tosylphenyl)pyridine 
• 1571060-03-1 4-methyl-N-(2-(pyridine-2-yl)-4-tosylphenyl)benzenesulfonamide 

Relevant academic research and scientific papers

Mechanistic insight into ruthenium catalysed: Meta -sulfonation of 2-phenylpyridine

The catalytic meta-functionalization of arenes has emerged as an important synthetic methodology in the last decade. We report herein structural and mechanistic studies of the meta-sulfonation of phenylpyridine using ruthenium complexes. Furthermore, we d

Ruthenium-catalyzed meta sulfonation of 2-phenylpyridines

A selective catalytic meta sulfonation of 2-phenylpyridines was found to occur in the presence of (arene)ruthenium(II) complexes upon reaction with sulfonyl chlorides. The 2-pyridyl group facilitates the formation of a stable Ru-Caryl σ bond that induces a strong para-directing effect. Electrophilic aromatic substitution proceeds with the sulfonyl chloride to furnish a sulfone at the position meta to the chelating group. This new catalytic process offers access to atypical regioselectivity for reactions involving chelation-assisted cyclometalation.