1350442-52-2Relevant academic research and scientific papers
Ruthenium-catalyzed meta sulfonation of 2-phenylpyridines
Saidi, Ourida,Marafie, Jameel,Ledger, Araminta E. W.,Liu, Po Man,Mahon, Mary F.,Kociok-Koehn, Gabriele,Whittlesey, Michael K.,Frost, Christopher G.
supporting information; experimental part, p. 19298 - 19301 (2012/01/31)
A selective catalytic meta sulfonation of 2-phenylpyridines was found to occur in the presence of (arene)ruthenium(II) complexes upon reaction with sulfonyl chlorides. The 2-pyridyl group facilitates the formation of a stable Ru-Caryl σ bond that induces a strong para-directing effect. Electrophilic aromatic substitution proceeds with the sulfonyl chloride to furnish a sulfone at the position meta to the chelating group. This new catalytic process offers access to atypical regioselectivity for reactions involving chelation-assisted cyclometalation.
