1350443-60-5

Basic information

• Product Name: methyl 4-[(4-methyl-3-nitrophenylamino)methyl]benzoate
• Synonyms: methyl 4-[(4-methyl-3-nitrophenylamino)methyl]benzoate
• CAS NO: 1350443-60-5
• Molecular Weight: 300.314
• Mol File: 1350443-60-5.mol

Chemical Properties

• CAS DataBase Reference: methyl 4-[(4-methyl-3-nitrophenylamino)methyl]benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-[(4-methyl-3-nitrophenylamino)methyl]benzoate(1350443-60-5)
• EPA Substance Registry System: methyl 4-[(4-methyl-3-nitrophenylamino)methyl]benzoate(1350443-60-5)

Safety Data

• Hazardous Substances Data: 1350443-60-5(Hazardous Substances Data)

Upstream product

• 386756-54-3 methyl 4-{[(4-methyl-3-nitrophenyl)imino]methyl}benzoate 
• 1571-08-0 methyl 4-formylbenzoate 
• 119-32-4 4-Methyl-3-nitroanilin 

Downstream Products

• 1350443-61-6 4-(4-methyl-3-nitrophenylaminomethyl)benzoic acid 
• 1350443-63-8 4-(4-methyl-3-nitrophenylaminomethyl)phenyl(4-methylpiperazin-1-yl)methanone 
• 1350443-67-2 [4-(3-amino-4-methylphenylaminomethyl)phenyl](4-methylpiperazin-1-yl)methanone 
• 1337552-31-4 4-[(3-amino-4-methylphenylamino)methyl]benzoic acid 
• 1427066-99-6 methyl 4-[(3-amino-4-methylphenylamino)methyl]benzoate 

Relevant articles and documents

Synthesis of N-aryl benzamides containing pharmacophoric tyrosine kinase inhibitor fragments

New N-aryl 4-(arylaminomethyl)benzamides containing pharmacophoric heterocyclic fragments have been synthesized from 2-arylaminopyrimidine, 1-methylpiperazine, and morpholine derivatives and substituted benzoic acids.

Functionally substituted Schiff bases in reduction reactions

Functionally substituted Schiff bases obtained by the condensation of nitroaniline, pyrimidinylaminoaniline, 5-aminoquinoline, 5-aminoquinaldine derivatives with 4-methylformylbenzoate were studied in the reactions of sodium borohydride with acidic activators, hydrazine hydrate in the presence of Raney nickel, Raney alloy in the presence of potassium hydroxide. By the reduction of azomethines new benzyl derivatives of aniline, quinolylamine, arylaminopyrimidine, and phenylenediamine were obtained.

Synthesis of new amides of the N-methylpiperazine series

New carboxylic acid amides containing an N-methylpiperazine fragment were synthesized by reactions of 1-methylpiperazine or 3- and 4-(4-methylpiperazin-1- ylmethyl)aniline with 4-chlorobenzoyl chloride and of 4-methyl-3-nitroaniline with 4-(4-methylpiperazin-1-ylmethyl)benzoyl chloride or benzotriazol-1-yl 4-(4-methylpiperazin-1-ylmethyl)benzoate. 4-Chloro-N-[4-(4-methylpiperazin-1- ylmethyl)phenyl]benzamide reacted with imidazole, quinolin-5-amine, and 2-methylquinolin-5-amine to give substituted 4-amino-N-[4-(4- methylpiperazin-1-ylmethyl)phenyl]benzamides. 4-Methyl-3-nitrophenyl-4- methylpiperazin-1-yl-substituted benzamides were reduced with hydrazine hydrate over Raney nickel to obtain N-(3-amino-4-methylphenyl)-4- (4-methylpiperazin-1- ylmethyl)benzamide as key intermediate in the synthesis of antileukemic agent imatinib and its isomer with alternative position of the amide group, 4-[(3-amino-4-methylphenylamino)methyl]phenyl- (4-methylpiperazin-1-yl)} methanone. Pleiades Publishing, Ltd., 2011.