1350454-75-9

Upstream product

• 815596-13-5 6-(3-Methoxyphenyl)-5-(2-(methylthio)pyrimidin-4-yl)imidazo[2,1-b]thiazole 
• 83069-19-6 C₁₀H₁₂F₃N₃O 
• 329-01-1 1-isocyanato-3-trifluoromethyl-benzene 
• 92754-06-8 6-(3-methoxyphenyl)imidazo[2,1-b]thiazole 
• 5000-65-7 2-bromo-3'-methoxyacetophenone 

Downstream Products

• 1350454-78-2 1-(2-(4-(6-(3-hydroxyphenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)-3-(3-(trifluoromethyl)phenyl)urea 

Relevant academic research and scientific papers

Imidazothiazole-based potent inhibitors of V600E-B-RAF kinase with promising anti-melanoma activity: biological and computational studies

A series of imidazothiazole derivatives possessing potential activity against melanoma cells were investigated for molecular mechanism of action. The target compounds were tested against V600E-B-RAF and RAF1 kinases. Compound 1zb is the most potent agains

New imidazo[2,1-b]thiazole derivatives: Synthesis, in vitro anticancer evaluation, and in silico studies

A series of 18 new imidazo[2,1-b]thiazole derivatives was synthesized. Their in vitro antiproliferative activities against A375P human melanoma cell line and NCI-60 cell line panel were tested. Compounds 15, 16, 18, 22, 26-28, and 31 showed superior poten