1350478-27-1Relevant articles and documents
Copper-Catalyzed Alkenylation of Cyanamides
Nitelet, Antoine,Wouters, Johan,Dewez, Damien F.,Evano, Gwilherm
, p. 6276 - 6279 (2017)
An efficient procedure for the copper-catalyzed cross-coupling between a broad range of cyanamides and iodoalkenes is reported. Upon reaction with catalytic amounts of copper(I) iodide and 2,2′-bisimidazole in the presence of cesium carbonate in DMF at 80 °C, a fast, regioselective, and stereoretentive cross-coupling occurs. This reaction, which was found to have a broad substrate scope, provides the first general entry to N-alkenylcyanamides, building blocks that hold great synthetic potential.