1350520-01-2

Upstream product

• 108334-64-1 N-tert-butyloxycarbonyl-L-valyl-L-phenylalanine 
• 1235568-25-8 tert-butyl (2S,5S)-5-((S)-1-azido-2-ethoxycarbonylmethyl)-1-benzylpyrrolidine-2-carboxylate 
• 1235568-61-2 C₁₃H₂₀N₂O₆ 
• 1350520-00-1 (S)-2-amino-N-(1-(benzylamino)-1-oxo-3-phenylpropan-2-yl)-3-methylbutanamide hydrochloride 
• 1235568-24-7 tert-butyl (2S,5S)-1-benzyl-5-(2-ethoxycarbonylmethyl)pyrrolidine-2-carboxylate 
• 1235568-30-5 tert-butyl (4S,4aS,7S)-4-(tert-butoxycarbonylamino)-1-oxohexahydro-1H-pyrrolo[1,2-c][1,3]oxazine-7-carboxylate 
• 100-46-9 benzylamine 
• 1350519-99-1 C₂₆H₃₅N₃O₄ 
• 1235568-29-2 tert-butyl (2S,5S)-1-benzyl-5-((S)-1-(tert-butoxycarbonylamino)-2-hydroxyethyl)pyrrolidine-2-carboxylate 
• 1235568-28-1 tert-butyl (2S,5S)-1-benzyl-5-((S)-1-(tert-butoxycarbonylamino)-2-ethoxycarbonylmethyl)pyrrolidine-2-carboxylate 

Downstream Products

• 1350520-02-3 C₃₆H₄₈N₆O₈ 
• 1350520-03-4 C₄₂H₅₈N₈O₁₀ 
• 1350520-04-5 C₃₉H₅₄N₆O₈ 
• 1350520-05-6 C₄₅H₆₄N₈O₁₀ 
• 1350520-06-7 C₄₅H₆₅N₉O₁₀ 
• 1350520-07-8 C₅₂H₆₉N₉O₁₁ 
• 1350519-93-5 (4S,4aS,7S)-4-amino-N-((S)-1-(1-(benzylamino)-1-oxo-3-phenylpropan-2-ylamino)-3-methyl-1-oxobutan-2-yl)-1-oxohexahydro-1H-pyrrolo[1,2-c][1,3]oxazine-7-carboxamide hydrochloride 
• 1350520-08-9 C₅₃H₇₁N₉O₁₁ 
• 1350520-09-0 C₅₃H₇₁N₉O₁₂ 
• 1350519-94-6 (4S,4aS,7S)-N-((S)-1-(1-(benzylamino)-1-oxo-3-phenylpropan-2-ylamino)-3-methyl-1-oxobutan-2-yl)-4-(2-guanidinoacetamido)-1-oxohexahydro-1H-pyrrolo[1,2-c][1,3]oxazine-7-carboxamide 
• 1350519-95-7 (4S,4aS,7S)-N-((S)-1-(1-(benzylamino)-1-oxo-3-phenylpropan-2-ylamino)-3-methyl-1-oxobutan-2-yl)-4-(5-guanidinopentanamido)-1-oxohexahydro-1H-pyrrolo[1,2-c][1,3]oxazine-7-carboxamide 
• 1350519-96-8 (4S,4aS,7S)-4-((S)-2-benzamido-5-guanidinopentanamido)-N-((S)-1-(1-(benzylamino)-1-oxo-3-phenylpropan-2-ylamino)-3-methyl-1-oxobutan-2-yl)-1-oxohexahydro-1H-pyrrolo[1,2-c][1,3]oxazine-7-carboxamide 
• 1350519-97-9 (4S,4aS,7S)-N-((S)-1-(1-(benzylamino)-1-oxo-3-phenylpropan-2-ylamino)-3-methyl-1-oxobutan-2-yl)-4-((S)-5-guanidino-2-(2-phenylacetamido)pentanamido)-1-oxohexahydro-1H-pyrrolo[1,2-c][1,3]oxazine-7-carboxamide 
• 1350519-98-0 benzyl (S)-1-((4S,4aS,7S)-7-((S)-1-(1-(benzylamino)-1-oxo-3-phenylpropan-2-ylamino)-3-methyl-1-oxobutan-2-ylcarbamoyl)-1-oxohexahydro-1H-pyrrolo[1,2-c][1,3]oxazin-4-ylamino)-5-guanidino-1-oxopentan-2-ylcarbamate 

Relevant academic research and scientific papers

Synthesis of GSK3β mimetic inhibitors of Akt featuring a novel extended dipeptide surrogate

Akt is a cardinal nodal point in PI3K signaling pathway and confers resistance to apoptosis through inactivation of regulatory substrates such as GSK3β. Efforts to inhibit the kinase activity of Akt have largely focused on targeting the ATP-binding domain