1350522-33-6Relevant articles and documents
Synthesis and SAR of a novel metabotropic glutamate receptor 4 (mGlu 4) antagonist: Unexpected 'molecular switch' from a closely related mGlu4 positive allosteric modulator
Utley, Thomas,Haddenham, Dustin,Salovich, James M.,Zamorano, Rocio,Vinson, Paige N.,Lindsley, Craig W.,Hopkins, Corey R.,Niswender, Colleen M.
scheme or table, p. 6955 - 6959 (2012/01/06)
Herein we report the discovery and SAR of a novel antagonist of metabotropic glutamate receptor 4 (mGlu4). The antagonist was discovered via a molecular switch from a closely related mGlu4 positive allosteric modulator (PAM). This antagonist (VU0448383) displays an IC50 value of 8.2 ± 0.4 μM and inhibits an EC80 glutamate response by 63.1 ± 6.6%.