135055-48-0

Upstream product

• 1008-88-4 3-phenylpyridine 
• 97-00-7 1-chloro-2,4-dinitro-benzene 

Downstream Products

• 1033950-85-4 (2E,4E)-2-phenyl-5-N,N-dimethylamino-2,4-pentadien-1-al 
• 97-02-9 2,4-Dinitroanilin 
• 1321996-78-4 N-(2-thiophenecarboylimino)-5-phenylpyridinium ylide 
• 1321996-77-3 N-(2-furoylimino)-5-phenylpyridinium ylide 
• 1222177-78-7 (6Z)-N-((2,E,4E)-5-(diethylamino)-2-phenylpenta-2,4-dienylidene)-2,4-dinitrobenzenamine 
• 1170871-47-2 5-(2,4-dinitrophenylamino)-2-phenylpenta-2,4-dienal 
• 1170871-59-6 5-(2,4-dinitrophenylamino)-4-phenylpenta-2,4-dienal 
• 135055-53-7 N-(4'-pyridylcarbonylimino)-3-phenylpyridinium ylide 
• 135055-54-8 N-(3'-pyridylcarbonylimino)-3-phenylpyridinium ylide 
• 135055-55-9 N-(2'-pyridylcarbonylimino)-3-phenylpyridinium ylide 
• 135055-65-1 N-(3'-pyridylcarbonylamino)-5-phenyl-1,2,3,6-tetrahydropyridine 
• 135055-64-0 N-(4'-pyridylcarbonylamino)-5-phenyl-1,2,3,6-tetrahydropyridine 
• 135055-66-2 N-(2'-pyridylcarbonylamino)-5-phenyl-1,2,3,6-tetrahydropyridine 
• 135055-67-3 N-(benzoylamino)-5-phenyl-1,2,3,6-tetrahydropyridine 

Relevant academic research and scientific papers

Synthesis of n-substituted carbonylamino-1,2,3,6-tetrahydropyridines as potential anti-inflammatory agents

Several N-substituted carbonyl/sulfonylamino-1,2,3,6-tetrahydropyridines (5a-i and 9a, b) were synthesized via sodium borohydride reduction of the corresponding N-substitutedimino-pyridinium ylides (4a-i and 8a, b) in absolute ethanol. Taylor &FrancisGroup, LLC.

Photochromic behavior of several new synthesized dyes via Zincke salts

Synthesis of several 'dyes', analogs of retinal imine visual pigment via nucleophilic attack of some secondary amines to pyridinium salts following precyclic ring-opening reaction, is discussed. The photochromic properties of these dyes have been studied by UV-Vis spectroscopy under irradiation of UV light. Copyright

Synthesis of δ-tributylstannyl-α,βγ, δ-unsaturated aldehydes from pyridines

(Equation Presented) Zincke aldehydes, which are readily available from the ring-opening reaction of pyridinium salts, are easily converted into δ-tributylstannyl-α,β,γ,δ-unsaturated aldehydes (stannyldienals) by the action of tributylstannyllithium. This reaction appears to proceed via 1,6-stannyllithium addition/elimination of lithium dialkylamide. Several stannyldienals of significant utility for the synthesis of polyene natural products have been made by this route, which proceeds in modest yields, but is successful on multigram scale using inexpensive reagents. Simple stannylenals and stannylenones are similarly available from the corresponding vinylogous amides.

Stereocontrolled synthesis of Z-dienes via an unexpected pericyclic cascade rearrangement of 5-amino-2,4-pentadienals

Donor-acceptor dienes known as Zincke aldehydes, which derive readily from the ring-opening reactions of pyridinium salts with secondary amines, undergo a fascinating thermal rearrangement reaction to afford Z-α,β,γ,δ-unsaturated amides with excellent stereoselectivity. Efficient, stereocontrolled access to Z-trisubstituted alkenes with two different substitution patterns is possible in three steps beginning with the appropriately substituted pyridine derivative. Preliminary studies have shown that both the amide and the monosubstituted alkene termini can be selectively functionalized. Ease of access, generality of scope, and facile product manipulation render this process attractive for the synthesis of complex polyenes. Copyright

Synthesis of Some N-(Phenylsulfonylamino)-1,2,3,6-tetrahydropyridines as Potential Anti-inflammatory Agents

Several N-(phenylsulfonylamino)-1,2,3,6-tetrahydropyridines were synthesized by substituting a sulfonyl group for the carbonyl group of N-(phenylcarbonylamino)-1,2,3,6-tetrahydropyridines 1 in order to investigate the effect of the substitution on the analgesic and anti-inflammatory activities. Nucleophilic attack of pyridine derivatives 2 on 1-chloro-2,4-dinitrobenzene 3 furnished the pyridinium chlorides 4. Compound 4 and benzenesulfonyl hydrazide 5 were reacted to give the 2,4-dinitroanilino derivatives 6. Hydrolysis of 6 furnished the ylides 7. Sodium borohydride reduction of ylides afforded the tetrahydropyridines 8. Compound 8c was found to be the most active anti-inflammatory agent and was as potent as indomethacin, the reference compound. Compound 8f had the most significant hyperglycemic activity.