1350557-83-3Relevant academic research and scientific papers
Total synthesis of the potent androgen receptor antagonist (-)-arabilin: A strategic, biomimetic [1,7]-hydrogen shift
Lim, Hee Nam,Parker, Kathlyn A.
, p. 20149 - 20151 (2012/02/02)
The first total synthesis of (-)-arabilin, a Streptomyces metabolite that inhibits hormone activation of the androgen receptor, has been completed. The key step, a [1,7]-hydrogen shift, establishes the enol ether-containing skipped-tetraene substructure. This nonenzymatic pericyclic reaction is considered to be biomimetic.
