135056-30-3Relevant academic research and scientific papers
Stereoselective Synthesis of Homochiral Alpha Substituted o-Methoxybenzyl Alcohols via Nucleophilic Additions to Kinetically Resolved Homochiral Tricarbonyl(η6-o-anisaldehyde)chromium(0)
Bromley, Lindsay A.,Davies, Stephen G.,Goodfellow, Craig L.
, p. 139 - 156 (1991)
Tricarbonyl(η6-o-anisaldehyde)chromium(0) has been kinetically resolved via the selective hydrolysis of one of the L-valinol derived imine diasteroisomers in the presence of deactivated alumina.An X-ray crystal structure analysis on the adduct formed between L-valinol and homochiral (+)-tricarbonyl(η6-o-anisaldehyde)chromium(0) unambiguously established the presence of the corresponding imine and not oxazolidine and confirmed the absolute configuration of the aldehyde complex.Addition of Grignard reagents to homochiral tricarbonyl(η6-o-anisaldehyde)chromium(0) occurs completely stereoselectively to give, following decomplexation, homochiral alpha substituted o-methoxybenzyl alcohols.
