1350622-33-1 Usage
General Description
Kb-NB77-78 is a class of chemicals known as benzofuran dual receptor antagonists that have been developed for potential use in the treatment of cocaine addiction. These compounds exhibit high selectivity for the kappa opioid receptor and the nociceptin/orphanin FQ peptide (NOP) receptor, which are both involved in the regulation of dopamine release in the brain. By targeting both of these receptors, kb-NB77-78 has shown promise in preclinical studies for reducing cocaine self-administration and drug-seeking behavior in animal models. This suggests that it may be a potential candidate for further development as a pharmacotherapy for cocaine addiction. However, further research is needed to fully understand its pharmacological effects and potential clinical applications.
Check Digit Verification of cas no
The CAS Registry Mumber 1350622-33-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,5,0,6,2 and 2 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1350622-33:
(9*1)+(8*3)+(7*5)+(6*0)+(5*6)+(4*2)+(3*2)+(2*3)+(1*3)=121
121 % 10 = 1
So 1350622-33-1 is a valid CAS Registry Number.
1350622-33-1Relevant articles and documents
PROTEIN KINASE D INHIBITORS
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Page/Page column 62-63, (2012/06/30)
Compounds according to Formula (I), are potent inhibitors of protein kinase D (pan-PKD) activity. PKD controls key signaling cascades in cells, affecting cell proliferation, gene transcription, and protein trafficking. Accordingly, pharmaceutically acceptable compositions of the inventive compounds are candidate therapeutics for pathological conditions conditioned by changes in PKD activity.
