1350648-20-2

Upstream product

• 1350648-21-3 7-iodo-1H-pyrazolo[4,3-b]pyridine-3-amine 
• 669066-35-7 3-fluoro-4-iodo-2-pyridinecarbonitrile 
• 97509-75-6 3-fluoropicolinonitrile 

Downstream Products

• 1350648-62-2 7-iodo-2-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)-2H-pyrazolo[4,3-b]pyridine 
• 1350648-63-3 7-iodo-1-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)-1H-pyrazolo[4,3-b]pyridine 
• 1350647-09-4 7-(2-(2,5-difluorophenyl)-5-methylpyridin-4-ylamino)-N-isopropyl-1H-pyrazolo[4,3-b]pyridine-1-carboxamide 
• 1350647-08-3 7-(2-(2,5-difluorophenyl)-5-methylpyridin-4-ylamino)-N-ethyl-1H-pyrazolo[4,3-b]pyridine-1-carboxamide 
• 1350649-17-0 N-(2-(2,5-difluorophenyl)-5-methylpyridin-4-yl)-1-(4-methoxybenzyl)-1H-pyrazolo[4,3-b]pyridin-7-amine 
• 1350649-18-1 N-(2-(2,5-difluorophenyl)-5-methylpyridin-4-yl)-2-(4-methoxybenzyl)-2H-pyrazolo[4,3-b]pyridin-7-amine 
• 1350647-07-2 N-(2-(2,5-difluorophenyl)-5-methylpyridin-4-yl)-1H-pyrazolo[4,3-b]pyridin-7-amine 
• 1350646-91-1 7-(2-(2,5-difluorophenyl)-5-methylpyrimidin-4-ylamino)-N-ethyl-1H-pyrazolo[4,3-b]pyridine-1-carboxamide 
• 1350649-08-9 N-(2-(2,5-difluorophenyl)-5-methylpyrimidin-4-yl)-1-(4-methoxybenzyl)-1H-pyrazolo[4,3-b]pyridin-7-amine 
• 1350649-07-8 N-(2-(2,5-difluorophenyl)-5-methylpyrimidin-4-yl)-2-(4-methoxybenzyl)-2H-pyrazolo[4,3-b]pyridin-7-amine 
• 1350646-90-0 N-(2-(2,5-difluorophenyl)-5-methylpyrimidin-4-yl)-1H-pyrazolo[4,3-b]pyridin-7-amine 

Relevant academic research and scientific papers

Design, synthesis and optimization of 7-substituted-pyrazolo[4,3-b]pyridine ALK5 (activin receptor-like kinase 5) inhibitors

A series of potent ALK5 inhibitors were designed using a SBDD approach and subsequently optimized to improve drug likeness. Starting with a 4-substituted quinoline screening hit, SAR was conducted using a ALK5 binding model to understand the binding site

PYRAZOLO[4,3-B]PYRIDINE-7-AMINE INHIBITORS OF ALK5

The present invention provides ALK5 inhibitors of the formula (I) wherein the variables are as defined herein. Also provided are pharmaceutical compositions, methods of making the compounds and intermediates thereof; and methods of using the compounds.